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Protein

Cation-transporting ATPase HMA5

Gene

HMA9

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metal efflux transporter that may play a role in detoxification of heavy metals, such as zinc, copper, lead and cadmium, especially in the shoots.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62CopperPROSITE-ProRule annotation1
Metal bindingi65CopperPROSITE-ProRule annotation1
Metal bindingi144CopperPROSITE-ProRule annotation1
Metal bindingi147CopperPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDetoxification, Ion transport, Transport
LigandCadmium, Copper, Lead, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-OSA-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting ATPase HMA5Curated (EC:3.6.3.-Curated)
Alternative name(s):
Protein HEAVY METAL ATPASE 5Curated
Short name:
OsHMA51 Publication
Gene namesi
Name:HMA91 Publication
Ordered Locus Names:Os06g0665800Imported, LOC_Os06g45500Curated
ORF Names:P0473H04.28Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Transmembranei938 – 958HelicalSequence analysisAdd BLAST21
Transmembranei966 – 986HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions, but mutant plants exhibit increased sensitivity to elevated levels of zinc, copper, lead, and to a lesser extent cadmium.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004409671 – 1003Cation-transporting ATPase HMA5Add BLAST1003

Proteomic databases

PaxDbiA0A0P0X004

Expressioni

Tissue specificityi

Expressed in root vascular cylinder, vascular bundles and mesophyll cells of leaf blades, and anther walls and microspores of stamens.1 Publication

Inductioni

Induced by high concentrations of copper, zinc and cadmium.1 Publication

Gene expression databases

ExpressionAtlasiA0A0P0X004 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os06g45500.1

Structurei

3D structure databases

SMRiA0A0P0X004
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 118HMA 1PROSITE-ProRule annotationAdd BLAST67
Domaini134 – 200HMA 2PROSITE-ProRule annotationAdd BLAST67
Domaini208 – 272HMA 3PROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

OMAiQKCFLQI
OrthoDBiEOG093602FP

Family and domain databases

CDDicd00371 HMA, 2 hits
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 2 hits
PRINTSiPR00120 HATPASE
SUPFAMiSSF55008 SSF55008, 2 hits
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
TIGR00003 TIGR00003, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 2 hits
PS50846 HMA_2, 3 hits

Sequencei

Sequence statusi: Complete.

A0A0P0X004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHLQLSAVA GGGRPAAAGG GGDEMEDVRL LDSYDEEMGG GAAAAAAGEE
60 70 80 90 100
EEAHVRVTGM TCSACTSAVE GAVSARRGVR RVAVSLLQNR AHVVFDPALL
110 120 130 140 150
KVEDIIEAIE DAGFDAEIIP DTAISQPKAQ KTLSAQFRIG GMTCANCVNS
160 170 180 190 200
VEGILKRLSG VKGAVVALAT SLGEVEYDPS VINKDEIVEA IEDAGFEAAF
210 220 230 240 250
LQSSEQDKIL LGLTGLHTER DVNVLHDILK KMIGLRQFDV NATVSEVEII
260 270 280 290 300
FDPEAVGLRS IVDAIETGSN GRLKAHVQNP YARGASNDAH EAAKMLHLLR
310 320 330 340 350
SSLFLSIPVF FIRMVCPHIP FIRSILMMHC GPFHMGDLLK WILVSIVQFV
360 370 380 390 400
VGKRFYIAAY RALRHGSTNM DVLVVLGTTA SYVYSVCALL YGAFTGFHPP
410 420 430 440 450
IYFETSAMII TFVLFGKYLE VLAKGKTSDA IKKLVELVPA TALLLLKDKE
460 470 480 490 500
GKYTEEREID ALLVQPGDIL KVLPGSKVPA DGVVVWGTSH VNESMITGES
510 520 530 540 550
APIPKEVSSA VIGGTMNLHG VLHIQANKVG SETVLSQIIS LVETAQMSKA
560 570 580 590 600
PIQKFADYVA SIFVPIVITL SMITFLVWFL CGWVGAYPNS WISGTSNCFV
610 620 630 640 650
FSLMFAIAVV VIACPCALGL ATPTAVMVAT GVGANHGVLV KGGDALERAQ
660 670 680 690 700
NVNYVIFDKT GTLTQGKAVV TTAKVFSGMD LGDFLTLVAS AEASSEHPLA
710 720 730 740 750
KAIVEYAFHF HFFGKLPTSK DGIEQRKEDR LSQLLLQVED FSALPGKGVQ
760 770 780 790 800
CLINGKRVLV GNRTLVTENG VNVPPEAENF LVDLELNAKT GILVSYDDDF
810 820 830 840 850
VGLMGITDPL KREAAVVVEG LKKMGVHPVM LTGDNWRTAK AVAKEVGIED
860 870 880 890 900
VRAEVMPAGK ADVVRSLQKD GSIVAMVGDG INDSPALAAA DVGMAIGGGT
910 920 930 940 950
DIAIEAADYV LVRNNLEDVI TAIDLSRKTF SRIRWNYFFA MAYNVVAIPV
960 970 980 990 1000
AAGALFPFTR LQMPPWLAGA CMAFSSVSVV CSSLLLRRYR KPRLTTVLQI

TVE
Length:1,003
Mass (Da):107,358
Last modified:January 20, 2016 - v1
Checksum:i978BA8041B2D14E9
GO

Sequence cautioni

The sequence BAD45393 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF20219 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003628 Genomic DNA Translation: BAD45393.1 Sequence problems.
AP008212 Genomic DNA Translation: BAF20219.2 Sequence problems.
AP014962 Genomic DNA Translation: BAS99032.1
AK241795 mRNA No translation available.
RefSeqiXP_015643579.1, XM_015788093.1
UniGeneiOs.47769

Genome annotation databases

EnsemblPlantsiOs06t0665800-01; Os06t0665800-01; Os06g0665800
GeneIDi4341778
GrameneiOs06t0665800-01; Os06t0665800-01; Os06g0665800
KEGGiosa:4341778

Similar proteinsi

Entry informationi

Entry nameiHMA9_ORYSJ
AccessioniPrimary (citable) accession number: A0A0P0X004
Secondary accession number(s): Q0DAA4, Q655X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: January 20, 2016
Last modified: March 28, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health