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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Bacteroides vulgatus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotationSAAS annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, Lyase
Biological processPyrimidine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
ORF Names:BvMPK_3819Imported, ERS852457_02902Imported, ERS852509_03910Imported, ERS852556_02285Imported, SAMN04487923_101618Imported
OrganismiBacteroides vulgatusImported
Taxonomic identifieri821 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000095660 Componenti: Unassembled WGS sequence
  • UP000183096 Componenti: Unassembled WGS sequence
  • UP000095333 Componenti: Unassembled WGS sequence
  • UP000095467 Componenti: Unassembled WGS sequence
  • UP000061587 Componenti: Chromosome

Structurei

3D structure databases

SMRiA0A0P0M5E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 255OMPdecaseInterPro annotationAdd BLAST240

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0P0M5E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQQLFENI QKKKSFLCVG LDTDIKKIPE HLLKEEDPIF AFNKAIIDAT
60 70 80 90 100
APYCIAYKPN LAFYESMGVK GWIAFEKTVS YIKENYPDQF IIADAKRGDI
110 120 130 140 150
GNTSAMYART FFEELDIDSV TVAPYMGEDS VTPFLSYEGK WVILLALTSN
160 170 180 190 200
KGSHDFQLTE DTNGERLFEK VLRKSQEWAN DENMMYVVGA TQGRAFEDIR
210 220 230 240 250
KIVPNHFLLV PGIGAQGGSL EEVCKYGMNS TCGLIVNSSR AIIYADKTEN
260 270
FATVAGQEAQ KVQAQMEKIM CQ
Length:272
Mass (Da):30,600
Last modified:January 20, 2016 - v1
Checksum:iC376240C83A23AE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP013020 Genomic DNA Translation: ALK86379.1
CYZI01000020 Genomic DNA Translation: CUO84464.1
CZAN01000049 Genomic DNA Translation: CUQ00528.1
CZBK01000011 Genomic DNA Translation: CUQ24195.1
FOBA01000016 Genomic DNA Translation: SEK86461.1
RefSeqiWP_005843024.1, NZ_PUEN01000007.1

Genome annotation databases

EnsemblBacteriaiALK86379; ALK86379; BvMPK_3819
GeneIDi5301065
PATRICifig|821.40.peg.4584

Similar proteinsi

Entry informationi

Entry nameiA0A0P0M5E2_BACVU
AccessioniPrimary (citable) accession number: A0A0P0M5E2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: May 23, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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