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Protein

4-hydroxy-4-methyl-2-oxoglutarate aldolase

Gene

rraA

Organism
Mycobacterium fortuitum
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.UniRule annotationSAAS annotation

Catalytic activityi

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate.UniRule annotationSAAS annotation
Oxaloacetate = pyruvate + CO2.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-4-methyl-2-oxoglutarate aldolaseUniRule annotationSAAS annotation (EC:4.1.1.3UniRule annotation, EC:4.1.3.17UniRule annotationSAAS annotation)
Short name:
HMG aldolaseUniRule annotation
Alternative name(s):
Oxaloacetate decarboxylaseUniRule annotation
Gene namesi
Name:rraAImported
ORF Names:XA26_58360Imported
OrganismiMycobacterium fortuitumImported
Taxonomic identifieri1766 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000057134 Componenti: Chromosome

Interactioni

Subunit structurei

Homotrimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class II aldolase/RraA-like family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK02553.

Family and domain databases

CDDicd16841. RraA_family. 1 hit.
Gene3Di3.50.30.40. 1 hit.
InterProiView protein in InterPro
IPR010203. RraA.
IPR005493. RraA/RraA-like.
IPR036704. RraA/RraA-like_sf.
PfamiView protein in Pfam
PF03737. RraA-like. 1 hit.
SUPFAMiSSF89562. SSF89562. 1 hit.
TIGRFAMsiTIGR01935. NOT-MenG. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0N9YJ74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIEPRATAD LVDEIYPDVR SCDLQLQNYG GRTMFAGPIT TVRCFQDNAL
60 70 80 90 100
LKSILSTPGD GGVLVVDGNG SLHTALVGDI IAGLAAEHGW SGVIVHGAVR
110 120 130 140 150
DAAALRTIDV GIKALGTNPR KGTKTGEGER DVEVSFGGVT FVPGEIAYAD
160
EDGIVVVGDD K
Length:161
Mass (Da):16,723
Last modified:January 20, 2016 - v1
Checksum:i1D64E12380299DCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011269 Genomic DNA. Translation: ALI29621.1.
RefSeqiWP_054603743.1. NZ_LZSJ01000159.1.

Genome annotation databases

EnsemblBacteriaiALI29621; ALI29621; XA26_58360.
GeneIDi29427994.
KEGGimft:XA26_58360.
PATRICifig|1766.6.peg.5802.

Similar proteinsi

Entry informationi

Entry nameiA0A0N9YJ74_MYCFO
AccessioniPrimary (citable) accession number: A0A0N9YJ74
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: October 25, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported