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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Acidiplasma cupricumulans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, ExonucleaseUniRule annotation, Hydrolase, Multifunctional enzymeUniRule annotation, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Alternative name(s):
Exodeoxyribonuclease large subunitUniRule annotation (EC:3.1.11.1UniRule annotation)
Gene namesi
Name:polCUniRule annotation
ORF Names:AOG55_02550Imported
OrganismiAcidiplasma cupricumulansImported
Taxonomic identifieri312540 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesFerroplasmaceaeAcidiplasma
Proteomesi
  • UP000050301 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 824PolC_DP2InterPro annotationAdd BLAST817

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 97Sequence analysisAdd BLAST21
Coiled coili168 – 188Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAPiMF_00324 DNApol_II_L_arch, 1 hit
InterProiView protein in InterPro
IPR004475 PolC_DP2
IPR016033 PolC_DP2_N
PANTHERiPTHR42210 PTHR42210, 3 hits
PfamiView protein in Pfam
PF03833 PolC_DP2, 1 hit
PIRSFiPIRSF016275 PolC_DP2, 1 hit
TIGRFAMsiTIGR00354 polC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0N8VKF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDKKLDEYN NLIRKRVDEC YAIATEAKSL GRDISTEVEI PLANDMAERV
60 70 80 90 100
EELIHMKGIA SEIRELSKTM SREEVSLKIS KKVAEMLREN KDEALEKAVR
110 120 130 140 150
VGLAILTEGI LVAPLEGIKE VKIVKNDDGT DYADIVYSGP IRSAGGTAQA
160 170 180 190 200
LSVLITDIVR RELNVGAFKA TDEEVERYIE EIQAYNRRKH LQYLPSDDEI
210 220 230 240 250
RLVVKNSPVM IDGEGSEEEE ISGHRDMKRI KTNNIRGGMC LVLCEGLIQK
260 270 280 290 300
SKKVLKYTNI MNLKEWDILD KIGNHKKEEK GDKGEKYLRD IIAGRPVFGY
310 320 330 340 350
PNRPGGFRLR YGRSRLSGLA AASINPITMY ILDDFIAIGS QIKVELPGKA
360 370 380 390 400
AAITPCDTID GPTVLLKNGD HVKIKNMEEA RSLRENIDVI TDLGEILIAY
410 420 430 440 450
GDFLENNRNL SRSPFTVEWW SYYLPDKLKG YEKTVPDQFT AVDLSRKYKI
460 470 480 490 500
PLHPKYDYYW HDITIDELKK LIDSIKVADF SGGLILTHDI RDILIKLGIE
510 520 530 540 550
FKNTDNGLFL SEFYPLIIST GFELVNDKIV QLRNIDNETN VMDAVNKLSG
560 570 580 590 600
IEIKPRAPVR VGARLGRPEK AGDRKMKPKV HALFPILNYG DSRRSILVAA
610 620 630 640 650
KNRVEFSMEL NARQCRNCGN ETPLTLCEKC GSITYDENTE KKLSVNVGTV
660 670 680 690 700
LEKAESHVGF YDLKELKGVK KLMSKSNTVE PLEKGILRSK YDISLNKDGT
710 720 730 740 750
CRYDMSDIPI THFKKSELKL SSETLKNLGY PDQEINEIYP QDIIIPEDAA
760 770 780 790 800
KYLLHVSNFI DDLLVKYYNM QPYYMCSKIE DLIGHLVIGL APHTSGGIVG
810 820 830 840 850
RIIGFSKVSG CYAHPFFHAA KRRNCDGDED SIMLLLDGLL NFSKKFLPST
860 870 880 890 900
TGGLMDAPLV LTVILDPEEV DKEALNVDTL YKYPLEFYLE TEKNSPASSI
910 920 930 940 950
EKMMKTMKVK MAEENSYTGA GFSFDTSDLS DGTLTSAYKT IGSMEEKIEK
960 970 980 990 1000
QLGLAKKLIS VDENDVAARV ISSHFLPDMF GNLRSFFTQE FRCTKCNSKF
1010 1020 1030 1040 1050
RRIPLSGKCL KCGSDNLILT IHHGSIVKYL KETEKIMSEF KLPEYLQAQI
1060 1070
RRLIDSINDT FDIHGDEIVD DAPTLESFK
Length:1,079
Mass (Da):121,779
Last modified:January 20, 2016 - v1
Checksum:i0C5FC27C16ADA6B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LKBH01000304 Genomic DNA Translation: KQB33580.1
RefSeqiWP_048102016.1, NZ_LKBH01000304.1

Genome annotation databases

EnsemblBacteriaiKQB33580; KQB33580; AOG55_02550

Similar proteinsi

Entry informationi

Entry nameiA0A0N8VKF5_9EURY
AccessioniPrimary (citable) accession number: A0A0N8VKF5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: February 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health