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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic

Gene

accD

Organism
Solanum nigrum (Black nightshade)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi242ZincUniRule annotation1
Metal bindingi245ZincUniRule annotation1
Metal bindingi261ZincUniRule annotation1
Metal bindingi264ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri242 – 264C4-typeUniRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation, TransferaseImported
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplasticUniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotationImported
ORF Names:SoniCp030Imported
Encoded oniPlastid; ChloroplastImported
OrganismiSolanum nigrum (Black nightshade)Imported
Taxonomic identifieri4112 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChloroplastImported, Plastid

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).SAAS annotation
Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and two subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 507CoA carboxyltransferase N-terminalInterPro annotationAdd BLAST270

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri242 – 264C4-typeUniRule annotationAdd BLAST23

Keywords - Domaini

Zinc-fingerUniRule annotation

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0N7CJ03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIHLLYFHA NRGQENSMER WWFNSMVFKK EFERRCGLNK SMGSLGPMEN
60 70 80 90 100
TSEDPNRKVK NIHSCSNVDY LFGVKDIRNF ISDDTFLVSD RNGDSYSIYF
110 120 130 140 150
DIENLIFEID NDHSFLSELE SSFYSYRNSS YLNNGFRGED PYYNSYMSYM
160 170 180 190 200
YDTQYSWNNH INSCIDNYLQ SQICIDTSII SGSENYGDSY ISRAICSGES
210 220 230 240 250
RNSSENEGSS RRTRTKGSDL TIRESSNDLE VTQKYKHLWV QCENCYGLNY
260 270 280 290 300
KKFLKSKMNI CEQCGYHLKM SSSDRIELLI DPGTWDPMDE DMVSLDPIEF
310 320 330 340 350
HSEEEPYKDR IDSYQRKTGL TEAVQTGIGQ LNGIPVAIGV MDFQFMGGSM
360 370 380 390 400
GSVVGEKITR LIEHAANQNL PLIIVCASGG ARMQEGSLSL MQMAKIASAL
410 420 430 440 450
YDYQLNKKLF YVAILTSPTT GGVTASFGML GDIIIAEPNA YIAFAGKRVI
460 470 480 490 500
EQTLNKTVPE GSQAAEYLFQ KGLFDLIVPR NLLKSVLSEL FKLHAFFPLN

QKSSKIK
Length:507
Mass (Da):57,631
Last modified:January 20, 2016 - v1
Checksum:i4FFA57F3F8C401B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM489055 Genomic DNA. Translation: AKM21954.1.
KT375308 Genomic DNA. Translation: ALI31149.1.
RefSeqiYP_009171877.1. NC_028070.2.

Genome annotation databases

GeneIDi26047366.

Similar proteinsi

Entry informationi

Entry nameiA0A0N7CJ03_SOLNI
AccessioniPrimary (citable) accession number: A0A0N7CJ03
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: November 22, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)