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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Pinus strobus (Eastern white pine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotationSAAS annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:cox1Imported
Encoded oniMitochondrionImported
OrganismiPinus strobus (Eastern white pine)Imported
Taxonomic identifieri3348 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaPinidaePinalesPinaceaePinusStrobus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 519COX1InterPro annotationAdd BLAST519

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiView protein in InterPro
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR036927. Cyt_c_oxase-like_su1_sf.
IPR000883. Cyt_C_Oxase_1.
IPR033944. Cyt_c_oxase_su1_dom.
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiView protein in Pfam
PF00115. COX1. 1 hit.
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiView protein in PROSITE
PS50855. COX1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0N7AKF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLVRWPFP TNHKDIGTPH SIFGAIAGVM GTCFSVPIRM ELAQPGDQIL
60 70 80 90 100
GGNHQPHNVS ITAHASPMIP FMVMPAVIGG SGNWSVPIPI XXXXAFPRLN
110 120 130 140 150
NIPSRLLPPS LLLPLSPASV EVGSGTGWTV YPPLSGITSH SGGAADPAIS
160 170 180 190 200
SPHLTGVSSI SGAINFITTI PNMRGPGMTM HRSPLFVRSV PVTAFLLLSS
210 220 230 240 250
LPVPAGAITM LSTDRSFNTT FFDPAGGGDP ILYQHLFRFS GHPEVYIPIL
260 270 280 290 300
PGFGIISHIV STFSGKPVFG YPGMVYAMIS IGVPGFLVRA HHMFTVGSDV
310 320 330 340 350
DTRAHSTAAT MIIAVPTGIK ISSRIATMWG GSIRYKTPML SAAGSIFPST
360 370 380 390 400
IGGLTGIVLA NPGLDIALHD THYVVAHSHY VLSMGAVSAS SAGFHFRVGK
410 420 430 440 450
IPGRTYPETL GQIHLRITLF GVNSTFFPMH FLGLSGMPRR IPDYPDAYAG
460 470 480 490 500
WNALSSFGPY VSVVGIFRFF VVVTITLGGG YNKRCAPSPR AVEHNPTTPE
510 520
WMVQSPPALH TPEELPAIKE TL
Length:522
Mass (Da):55,466
Last modified:January 20, 2016 - v1
Checksum:i6A7C9A643F85972A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM672417 Genomic DNA. Translation: AJP33532.1.

Similar proteinsi

Entry informationi

Entry nameiA0A0N7AKF1_PINST
AccessioniPrimary (citable) accession number: A0A0N7AKF1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: October 25, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)