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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Photorhabdus heterorhabditis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotationSAAS annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotationSAAS annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseImported, LigaseUniRule annotationSAAS annotationImported, Transferase
Biological processPyridine nucleotide biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotationSAAS annotation (EC:6.3.4.21UniRule annotationSAAS annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
ORF Names:AM629_02425Imported
OrganismiPhotorhabdus heterorhabditisImported
Taxonomic identifieri880156 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus
Proteomesi
  • UP000037727 Componenti: Unassembled WGS sequence

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili130 – 157Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAPiMF_00570. NAPRTase. 1 hit.
InterProiView protein in InterPro
IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR036068. Nicotinate_pribotase_like_C.
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiView protein in Pfam
PF04095. NAPRTase. 1 hit.
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0N1IZ89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDATLIIK SLLDTDAYKL HMQQAVYHRY NDIPVVAEFR CRGDELLGEY
60 70 80 90 100
AEELRHQVNM MANLALTDAE FNYLANLPFF KADYLNWLKT FRFNPQQVNI
110 120 130 140 150
SVTGAGQLAI RISGLWHEVI MWEVPLLALI SELVHRHHAL NNAAENATNQ
160 170 180 190 200
LRKLIKLFYQ DAKEEGIDLS GFKLMDFGTR RRFSHSVQHA IVSELQQHFP
210 220 230 240 250
YLIGTSNYQL AQQLGLTPVG TQAHEWFQAH QQISPELANS QREALQNWLN
260 270 280 290 300
EYPNQLGIAL TDCITMDAFL RDFDAQLANS YQGLRHDSGD PVQWGEKAIA
310 320 330 340 350
HYQKLGIDPI TKTLVFSDSL DFQKALTLYR HFHNRINLIF GIGTRLTCNI
360 370 380 390 400
PGVNPLNIVI KLIECNGKPV AKLSDSPGKT ICEDNEFVNR LRAAFDIPQI

KQAC
Length:404
Mass (Da):46,031
Last modified:December 9, 2015 - v1
Checksum:i73CA38AAB40DA460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LJCS01000003 Genomic DNA. Translation: KOY63667.1.
RefSeqiWP_054475807.1. NZ_LJCS01000003.1.

Genome annotation databases

EnsemblBacteriaiKOY63667; KOY63667; AM629_02425.
PATRICifig|880156.5.peg.570.

Similar proteinsi

Entry informationi

Entry nameiA0A0N1IZ89_9GAMM
AccessioniPrimary (citable) accession number: A0A0N1IZ89
Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: October 25, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported