Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Actinobacteria bacterium OK006
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei736ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:OK006_4248Imported
OrganismiActinobacteria bacterium OK006Imported
Taxonomic identifieri1592326 [NCBI]
Taxonomic lineageiBacteriaActinobacteria
Proteomesi
  • UP000037912 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 170tRNA-synt_1gInterPro annotationAdd BLAST104
Domaini299 – 503tRNA-synt_1_2InterPro annotationAdd BLAST205
Domaini809 – 922Anticodon_1InterPro annotationAdd BLAST114

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi733 – 737"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0N0MXH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETNPAAAS EVAAPHRYTA AMAAEIEARW QDFWDAEGTY EAPNPSGDLA
60 70 80 90 100
GDPELAAKPK KFIMDMFPYP SGAGLHVGHP LGYIATDVFA RFQRMTGHNV
110 120 130 140 150
LHTLGFDAFG LPAEQYAVQT GTHPRVSTEA NIENMKAQLR ALGLGHDKRR
160 170 180 190 200
SFATIDPEYY KWTQWIFLQI FNSWYDDEAD KARPISVLIA QFESGERAVP
210 220 230 240 250
SIDGATRAWN ELTATERADI LSEYRLAYAS DAPVNWSPGL GTVLANEEVT
260 270 280 290 300
ADGRSERGNF PVFKAKLRQW NMRITAYADR LLDDLEALDW PEAIKLQQRN
310 320 330 340 350
WIGRSEGARV DFPIDGEAIT VFTTRPDTLF GATYMVLAPE HPLVDKFVPE
360 370 380 390 400
AWPEGSHEVW TGGHATPAEA VAAYRAQAAS KSDVERQAEA KDKTGVFTGA
410 420 430 440 450
YATNPVNGEQ VPVFIADYVL MGYGTGAIMA VPAGDQRDFE FARAFELPIR
460 470 480 490 500
CIVEPVDGRG TDTSTWENAF GSYDAKIINS SNDDISLDGL AVSEAKERIT
510 520 530 540 550
EWLARKGIGE GTVNFRLRDW LFSRQRYWGE PFPIVYDEDG VAHALPESML
560 570 580 590 600
PLELPEVEDY SPRTFDPDDA NTSPETPLSR NEDWVNVTLD LGDGRGPQKY
610 620 630 640 650
RRETNTMPNW AGSCWYELRY LDPHNDQKLV DPAIEQYWMG PREGQPHGGV
660 670 680 690 700
DLYVGGAEHA VLHLLYARFW SKVLYDLGYV SSVEPFHKLF NQGMIQAFVY
710 720 730 740 750
RDSRGIAVPA AEVEERDGAY YYQGEKVSRL LGKMGKSLKN AVTPDEICAE
760 770 780 790 800
YGADTLRLYE MAMGPLDVSR PWDTRAVVGQ YRLLQRLWRN VVDETTGEVT
810 820 830 840 850
VVDTPADEDT LRALHKAIDG VRQDLEGLRF NTAIAKVTEL NNHLTKVGGP
860 870 880 890 900
VARTVAEPLV LLVAPLAPHI AEELWRKLGH TDSVVHQDFP VADPAYVVDE
910 920 930 940 950
AVTCVVQIKG KVKARLEVSP SISDADLEKI ALADEKVVAA LDGAGIRKVI
960
VRAPKLVNIV TA
Length:962
Mass (Da):106,779
Last modified:December 9, 2015 - v1
Checksum:i64D4BADC7EE4A58E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LJCU01000165 Genomic DNA. Translation: KPI11368.1.
RefSeqiWP_054231945.1. NZ_LJCU01000165.1.

Genome annotation databases

EnsemblBacteriaiKPI11368; KPI11368; OK006_4248.
PATRICifig|1592326.3.peg.5263.

Similar proteinsi

Entry informationi

Entry nameiA0A0N0MXH3_9ACTN
AccessioniPrimary (citable) accession number: A0A0N0MXH3
Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: March 28, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported