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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Thermus aquaticus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB)
  2. Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC), Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processPyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotationImported
ORF Names:BVI061214_01410Imported
OrganismiThermus aquaticusImported
Taxonomic identifieri271 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000037685 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 145OTCace_NInterPro annotationAdd BLAST144
Domaini151 – 294OTCaceInterPro annotationAdd BLAST144

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.13703 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0M9AGK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHLLDFEGW SRADLESVLD TARVMREVLE RPVKKVPALQ GFTVATVFFE
60 70 80 90 100
PSTRTRTSFE LAARRMSADV VSFAAQSSSL QKGESYKDTL LTLEAMGVDA
110 120 130 140 150
YVIRADAAGV PHQATRWVKG VVVNGGDGQR AHPTQALLDA YTLLEALGSL
160 170 180 190 200
EGKKIAIVGD ILHSRVARSG AELFSLLGAE VWCAGPPSLL PQSLPGARLT
210 220 230 240 250
PSLEEALEEA DAVMALRLQK ERMEAGLVNL EDYIARYQIT ERRLGLAKPQ
260 270 280 290 300
APLLHPGPMN RDVELEGTLA DSPRSLVNRQ VQNGVAVRMA VLYHLLVGRE

R
Length:301
Mass (Da):32,900
Last modified:December 9, 2015 - v1
Checksum:i7C6B029E3E457627
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LHCI01000106 Genomic DNA Translation: KOX90221.1
RefSeqiWP_053767828.1, NZ_LHCI01000106.1

Genome annotation databases

EnsemblBacteriaiKOX90221; KOX90221; BVI061214_01410
PATRICifig|271.14.peg.1486

Similar proteinsi

Entry informationi

Entry nameiA0A0M9AGK1_THEAQ
AccessioniPrimary (citable) accession number: A0A0M9AGK1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: March 28, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported