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Protein

Kynureninase

Gene

kynU_2

Organism
Labrenzia alba
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynU), Kynureninase (kynU_2)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU), Kynureninase (kynU_2)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (nbaC)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei95Pyridoxal phosphateUniRule annotation1
Binding sitei164Pyridoxal phosphateUniRule annotation1
Binding sitei193Pyridoxal phosphateUniRule annotation1
Binding sitei196Pyridoxal phosphateUniRule annotation1
Binding sitei218Pyridoxal phosphateUniRule annotation1
Binding sitei248Pyridoxal phosphateUniRule annotation1
Binding sitei274Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynU_2Imported
Synonyms:kynUUniRule annotation
ORF Names:LA5096_05547Imported
OrganismiLabrenzia albaImported
Taxonomic identifieri311410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeLabrenzia
Proteomesi
  • UP000049983 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 345Aminotran_5InterPro annotationAdd BLAST270

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 125Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase. 1 hit.
InterProiView protein in InterPro
IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiView protein in Pfam
PF00266. Aminotran_5. 1 hit.
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0M7AWZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQHPSDQN DNLRHKKDAF HLPEGVIYLD GNSLGVLPKH VPGRVADVVT
60 70 80 90 100
EQWGTSLIRA WNSHSWFDLP LRTGDRIGRL IGAPNGTVVA CDSTSVNVFK
110 120 130 140 150
VLSAALSLRP ERKVILSDSG NFPTDLYVAA GLKDLLAKGH ELKIVAPEEV
160 170 180 190 200
EAMLDDQVAA MMLTQVDYRT GRVHDMNDLT RKAHDAGAIA IWDLAHSAGA
210 220 230 240 250
IEVDLLGAKA DFAIGCGYKY LNGGPGAPAF LYVSPDHLDK VSSPLTGWMG
260 270 280 290 300
HEAPFAFDLD YRPVSGIACM TVGTPAILAL SSLHAALDIF EDVDMADIRA
310 320 330 340 350
KSISLSELFI AEVEARCPQL TLASPRSPSE RGSQVSFRFG EGYAVMQALI
360 370 380 390 400
ARGVIGDFRA PDVMRFGFAP LYLSHQDIVD AVAILADILD TGSWDRPEFK

TRAKVT
Length:406
Mass (Da):43,947
Last modified:December 9, 2015 - v1
Checksum:iCC03140BB695E349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CXWC01000015 Genomic DNA. Translation: CTQ78287.1.
RefSeqiWP_055119964.1. NZ_CXWE01000008.1.

Genome annotation databases

EnsemblBacteriaiCTQ78287; CTQ78287; LA5096_05547.

Similar proteinsi

Entry informationi

Entry nameiA0A0M7AWZ0_9RHOB
AccessioniPrimary (citable) accession number: A0A0M7AWZ0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: September 27, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported