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Protein

Glutamate--tRNA ligase

Gene

gltX-1

Organism
Coxiella burnetii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotationSAAS annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi103ZincUniRule annotation1
Metal bindingi105ZincUniRule annotation1
Metal bindingi130ZincUniRule annotation1
Metal bindingi132ZincUniRule annotation1
Binding sitei244ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltX-1Imported
Synonyms:gltXUniRule annotation
ORF Names:CBU_0205Imported
OrganismiCoxiella burnetiiImported
Taxonomic identifieri777 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Monomer.UniRule annotationSAAS annotation

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 24"HIGH" regionUniRule annotationAdd BLAST11
Motifi241 – 245"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00808. GluRS_core. 1 hit.
Gene3Di1.10.10.350. 1 hit.
1.10.8.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00022. Glu_tRNA_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020752. aa-tRNA-synth_I_codon-bd_sub1.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR033910. GluRS_core.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0M4Q097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPMKHIRT RFAPSPTGYL HIGGVRTALF SWLFARQNNG AFILRIEDTD
60 70 80 90 100
VARSTQASVD AILEGLRWLQ IDWNEGPYYQ SQRMDRYREV IEQLVKSDDA
110 120 130 140 150
YRCYCSKERL IELRNTQLKN KQKPRYDGFC RDKAPRQSNE PFVIRFRNPV
160 170 180 190 200
EGAVVFDDLI RGTISIDNRE LDDLIIARSD GGPTYNLTVV VDDWDMKITH
210 220 230 240 250
VIRGDDHINN TPRQINILHA LGAELPHYGH VPMILGPDGK RLSKRHGAVS
260 270 280 290 300
VLQYRDEGYL PEALMNYLIR LGWAHGDQEI FSREEMVQLF DISAVSRSPA
310 320 330 340 350
AFNPEKLLWL NQHYLKTVSP TIIAEAFATQ LEKAGTDLRN GPSLEQVIAL
360 370 380 390 400
QAERTKTLKE MAQRSLYFYQ EVRSYDEKAA RKHLLATIVE PLQRVRERLA
410 420 430 440 450
SLPSWEKEAI HEVIVETAQL HQLKLGQLAQ PIRVALTGDT VSPPIDATLY
460 470
LIGRDSALKR LDHAIRFIHQ GMG
Length:473
Mass (Da):54,126
Last modified:December 9, 2015 - v1
Checksum:i1B6FCD328D5AD8FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KT381467 Genomic DNA. Translation: ALE59680.1.
RefSeqiWP_010957435.1. NZ_NOLV01000002.1.

Genome annotation databases

GeneIDi31484482.
PATRICifig|777.21.peg.266.

Similar proteinsi

Entry informationi

Entry nameiA0A0M4Q097_COXBE
AccessioniPrimary (citable) accession number: A0A0M4Q097
Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: March 28, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)