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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bacillus gobiensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotationSAAS annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ), Phosphoribosylformylglycinamidine synthase subunit PurL (purL), Phosphoribosylformylglycinamidine synthase subunit PurS (purS)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotation
Biological processPurine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationSAAS annotation (EC:6.3.3.1UniRule annotationSAAS annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
ORF Names:AM592_21960Imported
OrganismiBacillus gobiensisImported
Taxonomic identifieri1441095 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000067625 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 160AIRSInterPro annotationAdd BLAST89
Domaini173 – 340AIRS_CInterPro annotationAdd BLAST168

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiView protein in InterPro
IPR010918. PurM-like_C_dom.
IPR036676. PurM-like_C_sf.
IPR016188. PurM-like_N.
IPR036921. PurM-like_N_sf.
IPR004733. PurM_cligase.
PANTHERiPTHR10520. PTHR10520. 1 hit.
PfamiView protein in Pfam
PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0M3RAV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAYKNAGV DIEAGYEAVT RMKKHVERTK RAGVMGALGG FGGMFDLSEL
60 70 80 90 100
SYKKPVLISG TDGVGTKLKL AFQMDKHDTI GIDAVAMCVN DVLAQGAEPL
110 120 130 140 150
FFLDYLAVGK ADPAKIEAIV KGVADGCEQS GSALVGGETA EMPGLYSEEE
160 170 180 190 200
YDIAGFSVGV AEKDEIVTGK KIEAGHLLIG LSSSGLHSNG FSLVRKVLLE
210 220 230 240 250
EAGLDLNKSY SPFNRPLGEE LLEPTKIYVK PVLEALNTGK IDGMAHVTGG
260 270 280 290 300
GFIENLPRML PEGLGIEIDN GSWPVPPIFP FLQEKGNMSE EEMFNVFNMG
310 320 330 340
IGFVLAIKEK DLAEMIQLLE SNGEKAYVIG RVQAGSGVTI SGVNSL
Length:346
Mass (Da):36,825
Last modified:December 9, 2015 - v1
Checksum:i827603152B88B354
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP012600 Genomic DNA. Translation: ALC83876.1.
RefSeqiWP_053605750.1. NZ_CP012600.1.

Genome annotation databases

EnsemblBacteriaiALC83876; ALC83876; AM592_21960.
PATRICifig|1441095.3.peg.4845.

Similar proteinsi

Entry informationi

Entry nameiA0A0M3RAV8_9BACI
AccessioniPrimary (citable) accession number: A0A0M3RAV8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: March 28, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported