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Protein

Tubulin alpha chain

Gene
N/A
Organism
Ascaris lumbricoides (Giant roundworm)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha chainUniRule annotation
OrganismiAscaris lumbricoides (Giant roundworm)Imported
Taxonomic identifieri6252 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAscarididaeAscaris
Proteomesi
  • UP000036681 Componenti: Genome

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 278TubulinInterPro annotationAdd BLAST198
Domaini280 – 425Tubulin_CInterPro annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili450 – 470Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0M3HPG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIDDQEPMA RNVCELEVDS FTELESEDRE IISLHVGQAG VQIGSACWEL
60 70 80 90 100
YCVEHGITAD GIIVDKQKAL EEKNRFSDSS LTSFFADTAN GRASPRAILV
110 120 130 140 150
DLEPSVIDTI RTREYRNLFH PEQLISGKED AANNYARGHY TIGREFIDVV
160 170 180 190 200
IERTRKLAEN CDSLQGFFIF HSIGGGTGSG FAALIMERLS PEYGKKSELE
210 220 230 240 250
FCVYPAPQVS TAVVEPYNSV LTTHNTLEYS DCTFLVDNEA IYDICRRNLD
260 270 280 290 300
VERPSYTNLN RIISQVVSSV TASLRFEGVL NVDLNEFQTN LVPYPRIHFP
310 320 330 340 350
LTSFAPVISM EKAYHESLSV SEITSMCFES HNQMVKCDAR KGKYMAICLL
360 370 380 390 400
YRGDVVPKDV NSAINSIKRK RVCDFVDWCP TGFKVGINYQ APVVVDGSDM
410 420 430 440 450
ARVERSVCTL ANTTAIAEAW SRLNVKFDLM YKKRAFVHWY VGEGMEEGEF
460 470
AEAREDMAAL EKDYEEVIGS DTITEENEY
Length:479
Mass (Da):53,941
Last modified:November 11, 2015 - v1
Checksum:i27AAB09878AD883A
GO

Genome annotation databases

WBParaSiteiALUE_0000377601-mRNA-1; ALUE_0000377601-mRNA-1; ALUE_0000377601

Similar proteinsi

Entry informationi

Entry nameiA0A0M3HPG0_ASCLU
AccessioniPrimary (citable) accession number: A0A0M3HPG0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: February 28, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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