isdG

Functionⁱ

Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.UniRule annotation

Catalytic activityⁱ

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O₂ = biliverdin + Fe²⁺ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H₂O.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	6	IronUniRule annotation	1
Siteⁱ	66	Transition state stabilizerUniRule annotation	1
Metal bindingⁱ	76	Iron (heme axial ligand)UniRule annotation	1

GO - Molecular functionⁱ

heme binding Source: UniProtKB-UniRule
heme oxygenase (decyclizing) activity Source: UniProtKB-UniRule
iron ion binding Source: UniProtKB-UniRule
monooxygenase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

heme catabolic process Source: UniProtKB-UniRule
iron assimilation Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	MonooxygenaseUniRule annotationImported, Oxidoreductase
Ligand	HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heme-degrading monooxygenaseUniRule annotation (EC:1.14.14.18UniRule annotation) Alternative name(s): Heme oxygenaseUniRule annotation Iron-regulated surface determinantUniRule annotation Iron-responsive surface determinantUniRule annotation
Gene namesⁱ	Name:isdGUniRule annotation ORF Names:AMD02_03335Imported
Organismⁱ	Bacillus okuhidensisImported
Taxonomic identifierⁱ	136160 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus
Proteomesⁱ	UP000037240 Componentⁱ: Unassembled WGS sequence

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_01272

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A0A0M0KGR6.
SMRⁱ	A0A0M0KGR6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 92	ABMInterPro annotationAdd BLAST		91

Sequence similaritiesⁱ

Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.UniRule annotation

Family and domain databases

HAMAPⁱ	MF_01272. Heme_degrading_monooxygenase. 1 hit.
InterProⁱ	View protein in InterPro IPR007138. ABM_dom. IPR011008. Dimeric_a/b-barrel. IPR023953. IsdG.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03992. ABM. 1 hit.
SUPFAMⁱ	SSF54909. SSF54909. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51725. ABM. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A0M0KGR6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVIVTNTSKI TKGNGEKLIE RFNKVGKVEF MEGFLGLEVL LTENTKDFDE 
        60         70         80         90        100
VTVVTRWNTK DDFKNWTKSS AFRDAHSKRE VPEYILENKI SFYEVKVVRG 
       110 
PLTAAEAGND SQAQAQ

Length:116

Mass (Da):13,175

Last modified:November 11, 2015 - v1

Checksum:ⁱ87F6CFB28A691023

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	LILD01000001 Genomic DNA. Translation: KOO37994.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

LILD01000001 Genomic DNA. Translation: KOO37994.1.

Genome annotation databases

EnsemblBacteriaⁱ	KOO37994; KOO37994; AMD02_03335.
PATRICⁱ	fig\|136160.3.peg.909.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A0M0KGR6	Q9K7R6	Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	116	UniRef100_Q9K7R6	Cluster: Heme-degrading monooxygenase	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A0M0KGR6	Q9K7R6	Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	116	UniRef90_Q9K7R6	Cluster: Heme-degrading monooxygenase	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A0M0KGR6	Q9K7R6 A0A073JXS6 UPI00036938A2 A0A094XEH3 A0A0J5R0C6 A0A061PCH7 W4QJZ4 A0A060LXF3 W8A721 UPI000BA65F82 +351	Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) Bacillus manliponensis Bacillus fordii Bacillus alcalophilus ATCC 27647 = CGMCC 1.3604 Bacillus pseudalcaliphilus Geomicrobium sp. JCM 19039 Bacillus hemicellulosilyticus JCM 9152 Bacillus lehensis G1 Bacillus sp. JCM 19047 Bacillus clausii And more	116	UniRef50_Q9K7R6	Cluster: Heme-degrading monooxygenase	362

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	LILD01000001 Genomic DNA. Translation: KOO37994.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

LILD01000001 Genomic DNA. Translation: KOO37994.1.

3D structure databases

ProteinModelPortalⁱ	A0A0M0KGR6.
SMRⁱ	A0A0M0KGR6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	KOO37994; KOO37994; AMD02_03335.
PATRICⁱ	fig\|136160.3.peg.909.

Family and domain databases

HAMAPⁱ	MF_01272. Heme_degrading_monooxygenase. 1 hit.
InterProⁱ	View protein in InterPro IPR007138. ABM_dom. IPR011008. Dimeric_a/b-barrel. IPR023953. IsdG.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03992. ABM. 1 hit.
SUPFAMⁱ	SSF54909. SSF54909. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51725. ABM. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A0M0KGR6_9BACI
Accessionⁱ	A0A0M0KGR6Primary (citable) accession number: A0A0M0KGR6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 11, 2015
	Last sequence update:	November 11, 2015
	Last modified:	September 27, 2017
	This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - A0A0M0KGR6 (A0A0M0KGR6_9BACI)

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Heme-degrading monooxygenase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Caution

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A0M0KGR6 (A0A0M0KGR6_9BACI)

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Heme-degrading monooxygenase

isdG

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ