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Protein

Transcription-repair-coupling factor

Gene

mfd

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, HydrolaseUniRule annotation
Biological processDNA damage, DNA repairUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription-repair-coupling factorUniRule annotation (EC:3.6.4.-UniRule annotation)
Short name:
TRCFUniRule annotation
Gene namesi
Name:mfdUniRule annotation
ORF Names:AC784_01155Imported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000037093 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini499 – 656Helicase ATP-bindingInterPro annotationAdd BLAST158
Domaini669 – 833Helicase C-terminalInterPro annotationAdd BLAST165

Sequence similaritiesi

In the C-terminal section; belongs to the helicase family. RecG subfamily.UniRule annotation
In the N-terminal section; belongs to the UvrB family.UniRule annotation

Family and domain databases

CDDicd00079. HELICc. 1 hit.
HAMAPiMF_00969. TRCF. 1 hit.
InterProiView protein in InterPro
IPR036101. CarD-like/TRCF_dom_sf.
IPR003711. CarD-like/TRCF_domain.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR004576. Mfd.
IPR027417. P-loop_NTPase.
IPR037235. TRCF-like_C.
IPR005118. TRCF_C.
PfamiView protein in Pfam
PF02559. CarD_CdnL_TRCF. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF03461. TRCF. 1 hit.
SMARTiView protein in SMART
SM01058. CarD_TRCF. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00982. TRCF. 1 hit.
SUPFAMiSSF141259. SSF141259. 1 hit.
SSF143517. SSF143517. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00580. mfd. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0K9MVU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQSSLYRAL NKGFDYQILA CKDFKESELA KEVISYFKPN TKAILFPEFR
60 70 80 90 100
AKKNDDLRSF FEEFLQLLGG LREFYQALEN KQEAIIIAPI SALLHPLPKK
110 120 130 140 150
ELLESFKITL LEKYNLKDLK DKLFYYGYEI VDLVEVEGEA SFRGDIVDIY
160 170 180 190 200
APNSKAYRLS FFDTECESIK EFDPTTQMSL KEDWLEIEIP PTLFSLDEPS
210 220 230 240 250
YKDLKTKVEQ SPFNSFSKDL ISFGLWFLEE KANDLLHAYK SVISPRALEE
260 270 280 290 300
IQELASLNEL DCERFKLLKV LENAQGYEDL EIHAHALESF IALHSNRKIT
310 320 330 340 350
LLAPNKTILD NAVSTLEKSN IECVIAPFVL NFKTPDGIFI SLNSFERKKK
360 370 380 390 400
RQKSKLTLNE LNPGEWVVHD DYGVGVFSQL VQHSVLGSKR DFLEIAYWGE
410 420 430 440 450
DKLLLPVENL HLIARYVAQS DSVPIKDRLG KGSFLKLKAK VRAKLLEIAS
460 470 480 490 500
KIIELAAERN LILGKKMETH LAELEVFKSH AGFEYTSDQE KAIAEISKDL
510 520 530 540 550
SSKRVMDRLL SGDVGFGKTE VAMHAVFCAF LNGFQSALVV PTTLLAHQHF
560 570 580 590 600
ETLRARFENF GVKVARLDRY ASGKNKLLKA VELGLIDVLV GTHAILGAKF
610 620 630 640 650
KNLGLVVVDE EHKFGVKQKE ALKELSKSVH FLSMSATPIP RTLNMALSQI
660 670 680 690 700
KGISSLKTPP TDRKPSRTFL KEKNDELLKE IIHRELRRNG QIFYIHNHIA
710 720 730 740 750
SISKVKTKLE DLIPKLKIAI LHSQINANES EEIMLEFAKG SYQVLLCTSI
760 770 780 790 800
VESGIHLPNA NTIIIDNAQN FGLADLHQLR GRVGRGKKEG FCYFLIEDQK
810 820 830 840 850
SLNEQALKRL LALEKNSYLG SGESVAYHDL EIRGGGNLLG QDQSGHIKNI
860 870 880 890 900
GYALYTRMLE DAIYELSGGK KRLEKSVEIQ LGVSAFLNPE LIASDSLRLD
910 920 930 940 950
LYRRLSLCEN TDEVGQIHEE IEDRFGKIDD LSAQFLQIIT LKILANQLGI
960 970 980 990
IKLSNFNQNI TITYSAEKKE SLKAPSKDDN DILETLLKHL RAQISLKRR
Length:999
Mass (Da):113,244
Last modified:November 11, 2015 - v1
Checksum:i56161311982BC809
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LFBZ01000002 Genomic DNA. Translation: KMZ48443.1.
RefSeqiWP_050829518.1. NZ_LFBZ01000002.1.

Genome annotation databases

EnsemblBacteriaiKMZ48443; KMZ48443; AC784_01155.
PATRICifig|210.1946.peg.405.

Similar proteinsi

Entry informationi

Entry nameiA0A0K9MVU3_HELPX
AccessioniPrimary (citable) accession number: A0A0K9MVU3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: November 22, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported