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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacteroides fragilis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
ORF Names:AC239_07350Imported, BJP29_14600Imported, HMPREF2533_00228Imported
OrganismiBacteroides fragilisImported
Taxonomic identifieri817 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000176569 Componenti: Unassembled WGS sequence
  • UP000075608 Componenti: Unassembled WGS sequence
  • UP000094213 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 143Ldh_1_NInterPro annotationAdd BLAST141
Domaini148 – 303Ldh_1_CInterPro annotationAdd BLAST156

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

KOiK00024.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0K6BYL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVTVVGAG NVGATCANVL AFNEVADEVV MLDVKEGVSE GKAMDMMQTA
60 70 80 90 100
QLLGFDTTIV GCTNDYAQTA NSDVVVITSG IPRKPGMTRE ELIGVNAGIV
110 120 130 140 150
KSVAENLLKY SPNAIIVVIS NPMDTMTYLA LKSLGLPKNR VIGMGGALDS
160 170 180 190 200
SRFKYFLSQA LGCNANEVEG MVIGGHGDTT MIPLARLATY KGQPVSTLLS
210 220 230 240 250
EEKLNEVVAS TMVGGATLTK LLGTSAWYAP GAAGAYVVES IIHNQKKMVP
260 270 280 290 300
CSVMLEGEYG ESDLCIGVPV ILGKNGIEKI VELELNADEK AKFAASAAAV
310
HKTNAALKEV GAL
Length:313
Mass (Da):32,676
Last modified:November 11, 2015 - v1
Checksum:iF3C4B9F01445DC14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LTZK01000008 Genomic DNA. Translation: KXU51055.1.
LIDV01000041 Genomic DNA. Translation: OCR44217.1.
MKXL01000009 Genomic DNA. Translation: OGX97321.1.
RefSeqiWP_005791692.1. NZ_MTGH01000023.1.

Genome annotation databases

EnsemblBacteriaiCUA20316; CUA20316; MB0529_03712.
KXU51055; KXU51055; HMPREF2533_00228.
KEGGibfb:VU15_17890.
PATRICifig|817.54.peg.3425.

Similar proteinsi

Entry informationi

Entry nameiA0A0K6BYL6_BACFG
AccessioniPrimary (citable) accession number: A0A0K6BYL6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: November 22, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported