Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Porphyromonas gingivalis AJW4
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotationSAAS annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, Lyase
Biological processPyrimidine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
ORF Names:PGJ_00000630Imported
OrganismiPorphyromonas gingivalis AJW4Imported
Taxonomic identifieri1403336 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000069920 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA0A0K2J331
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 255OMPdecaseInterPro annotationAdd BLAST240

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0K2J331-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTKELFDRI CRKCSFLCVG LDTDVKKIPP HLLNEDDPIL AFNKAIIDAT
60 70 80 90 100
AEYCVAFKPN MAFYESMGSF GAHSFEKTIE YIRERYPDQF IIADAKRGDI
110 120 130 140 150
GNTSDMYARS FFEHLKVDAL TVSPYMGEDS ISPFLSYAGK FTVLLALTSN
160 170 180 190 200
KGSQDFQMMR DADGEYLFER VIRISQTWDN AGQLMYVVGA TQASMLKDIR
210 220 230 240 250
EIVPDAFLLV PGVGAQGGSL EDVAEYGMNA HCGLLVNASR SIIYADNTEG
260 270
FAAKAAGEAA AMQRQMEIAL RAKGLI
Length:276
Mass (Da):30,505
Last modified:November 11, 2015 - v1
Checksum:i236DDAC4AC3E1051
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011996 Genomic DNA Translation: ALA92706.1
RefSeqiWP_021665831.1, NZ_CP011996.1

Genome annotation databases

EnsemblBacteriaiALA92706; ALA92706; PGJ_00000630
PATRICifig|1403336.3.peg.62

Similar proteinsi

Entry informationi

Entry nameiA0A0K2J331_PORGN
AccessioniPrimary (citable) accession number: A0A0K2J331
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: December 20, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health