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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrobaculum sp. WP30
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:PYWP30_00241Imported
OrganismiPyrobaculum sp. WP30Imported
Taxonomic identifieri1227555 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000062500 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 677tRNA-synt_1InterPro annotationAdd BLAST663
Domaini712 – 827Anticodon_1InterPro annotationAdd BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionUniRule annotationAdd BLAST11
Motifi638 – 642"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

KOiK01869
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0K1DZ80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELSRFFIE LAGRWQKRWR EAKVFEPEPS PGTPKFFITA AYPYPNGAIH
60 70 80 90 100
IGHGRTYLIA DVLARFHRHF GRRVFYPMGF HYTGTPILTV AEVIAAGDKT
110 120 130 140 150
VMEEYMEIYG VPEEEMKKMG DPLYLARYFH LQSKRAMEAF GLSIDWTREF
160 170 180 190 200
TTIDPEYQRF IQWQFEKLRK KGLVVRGRHP VGWCPRHSMP VGAHDTKDDK
210 220 230 240 250
EPDIGQWTLI YFADGEGLTF PTATLRPETA PGVTNLWINP DADYVVAELN
260 270 280 290 300
GRRVVVSRDA AFRLSFQGEV KVLREARGRE FVGRWVQNPV TGEWVEIYEA
310 320 330 340 350
RFVDPKVGTG VVMSVPAHAP YDYAALRDMG LERLIPLIKV EGYGEYPAKE
360 370 380 390 400
VVERMGVKNQ TDPALEDATK EVYSAEYSRG VMREDVADLV ARHLPEPARS
410 420 430 440 450
MVRAVFKMYF AGRPVKEARE FISKWLVESG LGGVMYDIMN KPVYCRCGTE
460 470 480 490 500
IVVKVLEDQW FLNYGDPKWK EAARRLIEEM AMVPSDAKAH FLATVDWLDK
510 520 530 540 550
RACARTRGLG TPLPWSPGWV VESLSDSTIY MAYYTVIKKI RQFGLKPEQL
560 570 580 590 600
TEEFWDFVLL GVGDVGEVAK KTGVSPEALK AIREEFEYWY PLDSRNSGKD
610 620 630 640 650
LIPNHLTFFI FNHVAIFPSE KWPRQIVANG WVLREGEKMS KSKRNVLPLD
660 670 680 690 700
RAVEMYGPDP LRATLVIAAE VEQDLDFRDA EARRNAQQLM AIYALVQRIA
710 720 730 740 750
QTAEDRAPSW LDLWLASEVA QILERVKEAY QRVRVRQAAV DVLYNVKSAF
760 770 780 790 800
DQYLSMVERP SKLAVEAAKA WVIAMEPIAP HLAEELWAVL GGGGFAASAP
810 820 830 840 850
WPSLKADPAA LLAKRYVDML IEDVKKIPAF GPGTRKVAVY VNRRFEWAKA
860 870 880 890 900
ALSGDIRAAI QAGAPPQAAK RLVDLLKSLG EEVRSLVASV EKFDELEALT
910 920 930 940
SYKPYLEKAL GASVELYDAE DASAPDLGGK KKAALPLKPG IYLSS
Length:945
Mass (Da):106,824
Last modified:November 11, 2015 - v1
Checksum:i3BACC180C532E53B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP012158 Genomic DNA Translation: AKT33904.1

Genome annotation databases

EnsemblBacteriaiAKT33904; AKT33904; PYWP30_00241
KEGGipyw:PYWP30_00241
PATRICifig|1227555.3.peg.247

Similar proteinsi

Entry informationi

Entry nameiA0A0K1DZ80_9CREN
AccessioniPrimary (citable) accession number: A0A0K1DZ80
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: March 28, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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