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Protein

Hypoxanthine phosphoribosyltransferase

Gene

PVIIG_02072

Organism
Plasmodium vivax India VII
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine phosphoribosyltransferase (PVIIG_02072)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97Magnesium 1; via carbonyl oxygenCombined sources1
Metal bindingi99Magnesium 1; via carbonyl oxygenCombined sources1
Metal bindingi144Magnesium 2Combined sources1
Metal bindingi145Magnesium 2Combined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase
Biological processPurine salvageUniRule annotation
LigandMagnesiumUniRule annotationCombined sources, Metal-bindingUniRule annotationCombined sources, Nucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Gene namesi
ORF Names:PVIIG_02072Imported
OrganismiPlasmodium vivax India VIIImported
Taxonomic identifieri1077284 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Plasmodium)
Proteomesi
  • UP000053562 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HHUX-ray3.05A/B/C/D/E/F/G/H/I/J/K/L2-233[»]
ProteinModelPortaliA0A0J9SD35.
SMRiA0A0J9SD35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 205PribosyltranInterPro annotationAdd BLAST156

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
InterProiView protein in InterPro
IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0J9SD35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIPNNPGAG ENALEPIYIK DDDGYDIDTF LIPDHYKNYI TKVLIPNGVL
60 70 80 90 100
KNRIEKLAFD IKQVYRNEEF HVICLLKGSR GFFSALLKYL NRIHNYSSTE
110 120 130 140 150
SPKHLYVEHY VRVKSYCNDQ SLDRIEIVSE DLSCLKDKHV LIVEDIIDTG
160 170 180 190 200
KTLLKFCEYL KKFEVKTIAI TCLFIKRTPL WNGFKADFVG FSIPDAFVVG
210 220 230
YSLDYNEKFR DLDHLCLVND EGIKKFRTAP PTA
Length:233
Mass (Da):26,970
Last modified:October 14, 2015 - v1
Checksum:iD0C4A44BE9A5CD05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KQ234266 Genomic DNA. Translation: KMZ80854.1.

Genome annotation databases

EnsemblProtistsiKMZ80854; KMZ80854; PVIIG_02072.

Similar proteinsi

Entry informationi

Entry nameiA0A0J9SD35_PLAVI
AccessioniPrimary (citable) accession number: A0A0J9SD35
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: November 22, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported