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Protein

4-hydroxy-4-methyl-2-oxoglutarate aldolase

Gene

A5726_02215

Organism
Mycobacterium conceptionense
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.UniRule annotationSAAS annotation

Catalytic activityi

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate.UniRule annotationSAAS annotation
Oxaloacetate = pyruvate + CO2.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-4-methyl-2-oxoglutarate aldolaseUniRule annotationSAAS annotation (EC:4.1.1.3UniRule annotation, EC:4.1.3.17UniRule annotationSAAS annotation)
Short name:
HMG aldolaseUniRule annotation
Alternative name(s):
Oxaloacetate decarboxylaseUniRule annotation
Gene namesi
ORF Names:A5726_02215Imported, ACT17_27390Imported, AWB98_12500Imported
OrganismiMycobacterium conceptionenseImported
Taxonomic identifieri451644 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000093779 Componenti: Unassembled WGS sequence
  • UP000037594 Componenti: Unassembled WGS sequence
  • UP000193811 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homotrimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class II aldolase/RraA-like family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd16841. RraA_family. 1 hit.
Gene3Di3.50.30.40. 1 hit.
InterProiView protein in InterPro
IPR010203. RraA.
IPR005493. RraA/RraA-like.
IPR036704. RraA/RraA-like_sf.
PfamiView protein in Pfam
PF03737. RraA-like. 1 hit.
SUPFAMiSSF89562. SSF89562. 1 hit.
TIGRFAMsiTIGR01935. NOT-MenG. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0J8TZY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIEPRATAD LVDEIYPDVR SCDLQLQNYG GKAMFAGPIT TVRCFQDNAL
60 70 80 90 100
LKSILSTPGN GGVLVVDGDG SLHTALVGDI IAGLAADNGW SGVIVHGAVR
110 120 130 140 150
DAAALRTIDV GIKALGTNPR KGTKTGEGER DVEVSFGGVT FVPGEIAYAD
160
EDGIVVVAGG DD
Length:162
Mass (Da):16,628
Last modified:October 14, 2015 - v1
Checksum:i86CDC4308BDA1551
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LFOD01000037 Genomic DNA. Translation: KMV14953.1.
LZHX01000008 Genomic DNA. Translation: OBF28872.1.
LQOP01000014 Genomic DNA. Translation: ORV27750.1.
RefSeqiWP_043368310.1. NZ_MBGG01000038.1.

Genome annotation databases

EnsemblBacteriaiKMV14953; KMV14953; ACT17_27390.
OBF28872; OBF28872; A5726_02215.
PATRICifig|451644.5.peg.5648.

Similar proteinsi

Entry informationi

Entry nameiA0A0J8TZY7_9MYCO
AccessioniPrimary (citable) accession number: A0A0J8TZY7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: October 25, 2017
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported