Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase

Gene

VL00_14265

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_02860), Phospho-2-dehydro-3-deoxyheptonate aldolase (WI95_29895), Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_14265), Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_21645), Phospho-2-dehydro-3-deoxyheptonate aldolase (Bcep18194_A3826), Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_13870), Phospho-2-dehydro-3-deoxyheptonate aldolase (Bcep18194_B0086)
  2. 3-dehydroquinate synthase (aroB), 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK), Shikimate kinase (aroK), Shikimate kinase (aroK), Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA), 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC), Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00053; UER00084.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolaseUniRule annotation (EC:2.5.1.54UniRule annotation)
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthaseUniRule annotation
DAHP synthaseUniRule annotation
Phospho-2-keto-3-deoxyheptonate aldolaseUniRule annotation
Gene namesi
ORF Names:VL00_14265Imported
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)Imported
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000036081 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 358DAHP_synth_1InterPro annotationAdd BLAST295

Sequence similaritiesi

Belongs to the class-I DAHP synthase family.UniRule annotation

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
PANTHERiPTHR21225. PTHR21225. 1 hit.
PfamiView protein in Pfam
PF00793. DAHP_synth_1. 1 hit.
PIRSFiPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsiTIGR00034. aroFGH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0J5VXR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNLDNPSHD REVGSADATQ DTTRIDDVRI GAVRPLISPA LLLDELPVPA
60 70 80 90 100
ATQTLVEDTR RAIGDILHGR DDRLLLVVGP CSIHDHDQAL DYARRLKAAA
110 120 130 140 150
DALKDDLLIT MRVYFEKPRT TVGWKGYIND PRLDGSFRIN EGLRAARQLL
160 170 180 190 200
LDINALGLPA STEFLDLLSP QYIADLIAWG AIGARTTESQ SHRQLASGLS
210 220 230 240 250
CPIGFKNGTD GGVQVASDAI VAAAASHAFM GMTKMGMAAI FETRGNDDAH
260 270 280 290 300
VILRGGKNGP NYDAEHVEAS CAVLRKAGLR EQVMVDCSHA NSNKSHERQI
310 320 330 340 350
EVAQDLARQL GQGEHRIVGV MVESHLEAGR QDLKPGVPLK YGVSITDACL
360 370
SWTQTEPVLD VLADAVRQRR AQSRNA
Length:376
Mass (Da):40,796
Last modified:October 14, 2015 - v1
Checksum:i4E1F53B6A596D909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LDWF01000030 Genomic DNA. Translation: KML15623.1.
RefSeqiWP_048023775.1. NZ_LDWP01000031.1.

Genome annotation databases

EnsemblBacteriaiKML15623; KML15623; VL00_14265.
PATRICifig|482957.23.peg.2480.

Similar proteinsi

Entry informationi

Entry nameiA0A0J5VXR4_BURL3
AccessioniPrimary (citable) accession number: A0A0J5VXR4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: October 25, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported