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Protein

Putrescine aminotransferase

Gene

patA

Organism
Citrobacter sp. MGH109
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine.UniRule annotation

Catalytic activityi

Putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: putrescine degradation

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Putrescine aminotransferase (patA)
This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route), the pathway putrescine degradation and in Amine and polyamine degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00188; UER00290.

Names & Taxonomyi

Protein namesi
Recommended name:
Putrescine aminotransferaseUniRule annotation (EC:2.6.1.82UniRule annotation)
Alternative name(s):
Putrescine--2-oxoglutaric acid transaminaseUniRule annotation
Short name:
PATUniRule annotation
Short name:
PATaseUniRule annotation
Gene namesi
Name:patAUniRule annotation
ORF Names:SK37_04662Imported
OrganismiCitrobacter sp. MGH109Imported
Taxonomic identifieri1686382 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacterCitrobacter freundii complex
Proteomesi
  • UP000036589 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei321N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliA0A0J1Q9F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.UniRule annotation

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01276. Putres_aminotrans_3. 1 hit.
InterProiView protein in InterPro
IPR005814. Aminotrans_3.
IPR017747. Putrescine_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 2 hits.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03372. putres_am_tran. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0J1Q9F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSLQYLNQ YHVIRELREH ILNRLPSSAS ALACSAHALN LIEKRTLDHE
60 70 80 90 100
EMKSLNREVI EYFKEHVNPG FLEYRKSVTA GGDYGAVEWQ AGSLNTLVDT
110 120 130 140 150
QGQEFVDCLG GFGIFNVGHR NPVVVSAVQN QLAKQPLHSQ ELLDPLRAML
160 170 180 190 200
AKTLAALAPG KLKYSFFCNS GTESVEAALK LAKAYQSPRG KFTFIATSGA
210 220 230 240 250
FHGKSLGALS ATAKSTFRKP FMPLLPGFRH VPFGDVNAMR TMLSECKKTG
260 270 280 290 300
DDVAAVILEP IQGEGGVILP PQGYLTAVRK LCDEFGALMI LDEVQTGMGR
310 320 330 340 350
TGKMFACEHE NVQPDIMCLA KALGGGVMPI GATIATEEVF SVLFDNPFLH
360 370 380 390 400
TTTFGGNPLA CAAALATINV LLEQNLPAQA EQKGDMLLDG FRQLAREYPD
410 420 430 440 450
LVHDVRGKGM LMAIEFVDNE IGYNFASEMF RQRVLVAGTL NNAKTIRIEP
460 470 480
PLTLTIEQCD LVLRSTRKAL AALRVSVEQM
Length:480
Mass (Da):52,418
Last modified:April 13, 2016 - v1
Checksum:i2F982EB0E152FF9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LESR01000023 Genomic DNA. Translation: KLV74220.1.

Genome annotation databases

EnsemblBacteriaiKLV74220; KLV74220; SK37_04662.
PATRICifig|1686382.3.peg.4802.

Similar proteinsi

Entry informationi

Entry nameiA0A0J1Q9F0_9ENTR
AccessioniPrimary (citable) accession number: A0A0J1Q9F0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: September 27, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported