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Protein

Imidazoleglycerol-phosphate dehydratase

Gene

hisB

Organism
Nocardia farcinica
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotationSAAS annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG_1), ATP phosphoribosyltransferase (hisG_2), ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE), Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI), Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (priA_2)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB), Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD), Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00031; UER00011.

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazoleglycerol-phosphate dehydrataseUniRule annotationSAAS annotation (EC:4.2.1.19UniRule annotationSAAS annotation)
Short name:
IGPDUniRule annotation
Gene namesi
Name:hisBUniRule annotationImported
ORF Names:ERS450000_02266Imported
OrganismiNocardia farcinicaImported
Taxonomic identifieri37329 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000057820 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0H5NP55.
SMRiA0A0H5NP55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the imidazoleglycerol-phosphate dehydratase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01693.

Family and domain databases

CDDicd07914. IGPD. 1 hit.
HAMAPiMF_00076. HisB. 1 hit.
InterProiView protein in InterPro
IPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
PANTHERiPTHR23133. PTHR23133. 1 hit.
PfamiView protein in Pfam
PF00475. IGPD. 1 hit.
SUPFAMiSSF54211. SSF54211. 2 hits.
PROSITEiView protein in PROSITE
PS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0H5NP55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTTLRHRT ARVERVTKES SIVVELDLDG TGRTDISTGV PFYDHMLTAL
60 70 80 90 100
GAHASFDLSV RAEGDIQIEA HHTVEDTAIV FGQALGKALG DKAGIRRFGD
110 120 130 140 150
AFIPMDETLA HAAVDVSGRP YCVHTGEPEH LLHAVIPGSP VRGTGEPGAP
160 170 180 190 200
YSTVLNRHVF ESIALNARIA LHVRVLYGRD QHHVTEAEFK AVARALRAAV
210
EFDPRVSGVP STKGTL
Length:216
Mass (Da):23,301
Last modified:October 14, 2015 - v1
Checksum:iBBE36ED5192EA658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN868938 Genomic DNA. Translation: CRY77233.1.
RefSeqiWP_011208378.1. NZ_LN868938.1.

Genome annotation databases

EnsemblBacteriaiCRY77233; CRY77233; ERS450000_02266.
KEGGinfr:ERS450000_02266.

Similar proteinsi

Entry informationi

Entry nameiA0A0H5NP55_NOCFR
AccessioniPrimary (citable) accession number: A0A0H5NP55
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: September 27, 2017
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported