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Protein

Ornithine carbamoyltransferase

Gene

arcB

Organism
Staphylococcus aureus (strain USA300)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.SAAS annotation

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (arcB), Ornithine carbamoyltransferase (arcB), Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei89Carbamoyl phosphateUniRule annotation1
Binding sitei113Carbamoyl phosphateUniRule annotation1
Binding sitei172OrnithineUniRule annotation1
Binding sitei236OrnithineUniRule annotation1
Binding sitei322Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferaseUniRule annotationSAAS annotation (EC:2.1.3.3UniRule annotationSAAS annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:arcBImported
Synonyms:argFUniRule annotation
Ordered Locus Names:SAUSA300_2569Imported
OrganismiStaphylococcus aureus (strain USA300)Imported
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001939 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0H2XIV7.
SMRiA0A0H2XIV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 153OTCace_NInterPro annotationAdd BLAST141
Domaini159 – 332OTCaceInterPro annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 65Carbamoyl phosphate bindingUniRule annotation4
Regioni140 – 143Carbamoyl phosphate bindingUniRule annotation4
Regioni240 – 241Ornithine bindingUniRule annotation2
Regioni277 – 278Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00611.
OMAiHPMFLGK.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiView protein in InterPro
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
PfamiView protein in Pfam
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiView protein in PROSITE
PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0H2XIV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEIQKPYDL KGRSLLKESD FTKAEFEGLI DFAITLKEYK KNGIKHHYLS
60 70 80 90 100
GKNIALLFEK NSTRTRAAFT VASIDLGAHP EFLGKNDIQL GKKESVEDTA
110 120 130 140 150
KVLGRMFDGI EFRGFSQQAV EDLAKFSGVP VWNGLTDDWH PTQMLADFMT
160 170 180 190 200
IKENFGYLEG INLTYVGDGR NNIAHSLMVA GAMLGVNVRI CTPKSLNPKE
210 220 230 240 250
AYVDIAKEKA SQYGGSVMIT DNIAEAVENT DAIYTDVWVS MGEESEFEQR
260 270 280 290 300
INLLKDYQVN QQMFDLTGKD STIFLHCLPA FHDTNTLYGQ EIYEKYGLAE
310 320 330
MEVTDQIFRS EHSKVFDQAE NRMHTIKAVM AATLGS
Length:336
Mass (Da):37,763
Last modified:September 16, 2015 - v1
Checksum:iF87470583F496AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD21924.1.

Genome annotation databases

EnsemblBacteriaiABD21924; ABD21924; SAUSA300_2569.
KEGGisaa:SAUSA300_2569.

Similar proteinsi

Entry informationi

Entry nameiA0A0H2XIV7_STAA3
AccessioniPrimary (citable) accession number: A0A0H2XIV7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 16, 2015
Last sequence update: September 16, 2015
Last modified: June 7, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported