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Protein
Submitted name:

Sodium/potassium/calcium exchanger 3

Gene

Slc24a3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-RNO-425561. Sodium/Calcium exchangers.

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium/potassium/calcium exchanger 3Imported
Gene namesi
Name:Slc24a3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi69256. Slc24a3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei62 – 85HelicalSequence analysisAdd BLAST24
Transmembranei97 – 116HelicalSequence analysisAdd BLAST20
Transmembranei122 – 143HelicalSequence analysisAdd BLAST22
Transmembranei367 – 388HelicalSequence analysisAdd BLAST22
Transmembranei394 – 416HelicalSequence analysisAdd BLAST23
Transmembranei423 – 444HelicalSequence analysisAdd BLAST22
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Transmembranei496 – 519HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000060687.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 138Na_Ca_exInterPro annotationAdd BLAST137
Domaini359 – 510Na_Ca_exInterPro annotationAdd BLAST152

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili287 – 311Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. [View classification]SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119209.
OMAiVHLNKWQ.

Family and domain databases

InterProiView protein in InterPro
IPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030248. SLC24A3.
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF22. PTHR10846:SF22. 1 hit.
PfamiView protein in Pfam
PF01699. Na_Ca_ex. 2 hits.
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0G2K092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AMYMFYALAI VCDDFFVPSL EKICERLHLS EDVAGATFMA AGSSAPELFT
60 70 80 90 100
SVIGVFITKG DVGVGTIVGS AVFNILCIIG VCGLFAGQVV ALSSWCLLRD
110 120 130 140 150
SIYYTLSVVA LIVFIYDEKV SWWESLVLVL MYLIYIIIMK YNACIHQCFE
160 170 180 190 200
RRTKGAGNMV NGLANNAEID DSSNCDATVV LLKKANFHRK ASVIMVDELL
210 220 230 240 250
SAYPHQLSFS EAGLRIMITS HFPPKTRLSM ASRMLINERQ RLINSRAYTN
260 270 280 290 300
GESEVAIKIP IKHTENGTGP SSAPDRGVNG TRRDDIVAEA DNETENENED
310 320 330 340 350
ENNENDEEED EDDDEGPYTP FDPPSGKLET VKWAFTWPLS FVLYFTVPNC
360 370 380 390 400
NKPHWEKWFM VTFASSTLWI AAFSYMMVWM VTIIGYTLGI PDVIMGITFL
410 420 430 440 450
AAGTSVPDCM ASLIVARQGM GDMAVSNSIG SNVFDILIGL GLPWALQTLA
460 470 480 490 500
VDYGSYIRLN SRGLIYSVGL LLASVFVTVF GVHLNKWQLD KKLGCGCLFL
510 520
YGVFLCFSIM TEFNVFTFVN LPMCGD
Length:526
Mass (Da):58,221
Last modified:July 22, 2015 - v1
Checksum:i769BD6D7BEEAB424
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054088 Genomic DNA. No translation available.
AABR07054089 Genomic DNA. No translation available.
AABR07054090 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000089098; ENSRNOP00000071351; ENSRNOG00000060687.

Similar proteinsi

Entry informationi

Entry nameiA0A0G2K092_RAT
AccessioniPrimary (citable) accession number: A0A0G2K092
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: October 25, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported