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Protein
Submitted name:

KIT proto-oncogene receptor tyrosine kinase

Gene

Kit

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi566MagnesiumUniRule annotation1
Binding sitei621ATPUniRule annotation1
Binding sitei793ATPUniRule annotation1
Metal bindingi794MagnesiumUniRule annotation1
Metal bindingi807MagnesiumUniRule annotation1
Sitei933Important for interaction with phosphotyrosine-binding proteinsUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi594 – 601ATPUniRule annotation8
Nucleotide bindingi669 – 675ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-1433557. Signaling by SCF-KIT.
R-RNO-1433559. Regulation of KIT signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
KIT proto-oncogene receptor tyrosine kinaseImported
Gene namesi
Name:KitImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620568. Kit.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei523 – 546HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500254651926 – 974Sequence analysisAdd BLAST949

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000002227.
ExpressionAtlasiA0A0G2JTL4. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0G2JTL4.
SMRiA0A0G2JTL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 97Ig-likeInterPro annotationAdd BLAST61
Domaini212 – 310Ig-likeInterPro annotationAdd BLAST99
Domaini587 – 934Protein kinaseInterPro annotationAdd BLAST348

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118923.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR027263. SCGF_receptor.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001824. Tyr_kinase_rcpt_3_CS.
PfamiView protein in Pfam
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PIRSFiPIRSF500951. SCGF_recepter. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0G2JTL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGARGAWDL LCVLLVLLRG QTGTSQPSAS PGEPSPPSIQ PAQSELIVEA
60 70 80 90 100
GDTIRLTCTD PAFVKWTFEI LDVRIENKQS EWIREKAEAT HTGKYTCVSG
110 120 130 140 150
SGLRSSIYVF VRDPAVLFLV GLPLFGKEDN DALVRCPLTD PQVSNYSLIE
160 170 180 190 200
CDGKSLPTDL KFVPNPKAGI TIKNVKRAYH RLCIRCAAQR EGKWMRSDKF
210 220 230 240 250
TLKVRAAIKA IPVVSVPETS HLLKEGDTFT VICTIKDVST SVDSMWIKLN
260 270 280 290 300
PQPQSKAQVK RNSWHQGDFN YERQETLTIS SARVNDSGVF MCYANNTFGS
310 320 330 340 350
ANVTTTLKVV EKGFINIFPV KNTTVFVTDG ENVDLVVEFE AYPKPEHQQW
360 370 380 390 400
IYMNRTPTNR GEDYVKSDNQ SNIRYVNELR LTRLKGTEGG TYTFLVSNSD
410 420 430 440 450
VSASVTFDVY VNTKPEILTY DRLMNGRLQC VAAGFPEPTI DWYFCTGAEQ
460 470 480 490 500
RCTVPVPPVD VQIQNASVSP FGKLVVQSSI DSSVFRHNGT VECKASNAVG
510 520 530 540 550
KSSAFFNFAF KEQIQPHTLF TPLLIGFVVT AGLMGIIVMV LAYKYLQKPM
560 570 580 590 600
YEVQWKVVEE INGNNYVYID PTQLPYDHKW EFPRNRLSFG KTLGAGAFGK
610 620 630 640 650
VVEATAYGLI KSDAAMTVAV KMLKPSAHLT EREALMSELK VLSYLGNHMN
660 670 680 690 700
IVNLLGACTV GGPTLVITEY CCYGDLLNFL RRKRDSFIFS KQEEQADAAL
710 720 730 740 750
YKNLLHSKES SCDSSNEYMD MKPGVSYVVP TKTDKRRSAR IDSYIERDVT
760 770 780 790 800
PAIMEDDELA LDLEDLLSFS YQVAKGMAFL ASKNCIHRDL AARNILLTHG
810 820 830 840 850
RITKICDFGL ARDIRNDSNY VVKGNARLPV KWMAPESIFN CVYTFESDVW
860 870 880 890 900
SYGIFLWELF SLGSSPYPGM PVDSKFYKMI KEGFRMLSPE HAPAAMYEVM
910 920 930 940 950
KTCWDADPLK RPTFKQVVQL IEKQISDSSK HIYSNLANCN PNPENPVVVD
960 970
HSVRVNSVGS STSSTQPLLV HEDA
Length:974
Mass (Da):108,956
Last modified:July 22, 2015 - v1
Checksum:iB9BFAD9BA0DA190D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07014877 Genomic DNA. No translation available.
AABR07014878 Genomic DNA. No translation available.
AABR07014879 Genomic DNA. No translation available.
RefSeqiXP_006250971.1. XM_006250909.3.
UniGeneiRn.54004.

Genome annotation databases

EnsembliENSRNOT00000090654; ENSRNOP00000068756; ENSRNOG00000002227.
GeneIDi64030.

Similar proteinsi

Entry informationi

Entry nameiA0A0G2JTL4_RAT
AccessioniPrimary (citable) accession number: A0A0G2JTL4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: November 22, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported