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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Candidatus Uhrbacteria bacterium GW2011_GWF2_44_350
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi174 – 181ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation
Biological processDNA replicationUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
ORF Names:UW63_C0014G0013Imported
OrganismiCandidatus Uhrbacteria bacterium GW2011_GWF2_44_350Imported
Taxonomic identifieri1619000 [NCBI]
Taxonomic lineageiBacteriaCandidatus Uhrbacteria
Proteomesi
  • UP000034154 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini166 – 311AAAInterPro annotationAdd BLAST146
Domaini378 – 447Bac_DnaA_CInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
PANTHERiPTHR30050:SF2. PTHR30050:SF2. 1 hit.
PfamiView protein in Pfam
PF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
PRINTSiPR00051. DNAA.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0G1JIW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPMNTNELW QAVLGELELK LSKANFTTWF KQTFVATFNE NEVVIGVPNT
60 70 80 90 100
FTKTWLEKKY HKEIHNLIQT FASNSRIKNV IYKVETKPGL PVSIDPIEIE
110 120 130 140 150
EIINEIPPTS QQTYYPSPQS TLAQHRQETI EVSLNTKYAF SNFIVGKQNE
160 170 180 190 200
LAHAAAQAVA SQPGGVYNPL FLYGGVGLGK THLLQAVGNE IAKQNPKAKI
210 220 230 240 250
LYVTSEKFTN DYIYAIRTNR TREFKELYRT VDVLLIDDIQ FITGKEGTQE
260 270 280 290 300
EFFHTFNALH QNNKQIILTS DRPPKAIPDL EQRLSSRFEW GMMADIGSPD
310 320 330 340 350
FETRIAILQA KCREKNYLLE QDILHHIGTV VQSNVRELEG ALNKIIALHQ
360 370 380 390 400
FKNITPSIET VKPILVSFQP TKNKKSVTPR HLIQLVAGYF ELQIDDLLGK
410 420 430 440 450
SREKRLAFPR QIIMYIMREE MKSSFPSIGN ELGGRDHTTA MHAYEKISNQ
460 470
IAIDEKLQQD VELIKQRMYS
Length:470
Mass (Da):53,796
Last modified:July 22, 2015 - v1
Checksum:iA8B6B8C0C207A4AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LCJB01000014 Genomic DNA. Translation: KKT71541.1.

Genome annotation databases

EnsemblBacteriaiKKT71541; KKT71541; UW63_C0014G0013.
PATRICifig|1619000.3.peg.298.

Similar proteinsi

Entry informationi

Entry nameiA0A0G1JIW1_9BACT
AccessioniPrimary (citable) accession number: A0A0G1JIW1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: October 25, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported