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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported, TransferaseImported
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:6.4.1.2UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
ORF Names:BN1224_CV15_B_03520Imported, BN1224_GiD_A_04280Imported, BN1224_H12_DW_00460Imported, BN1224_MUL2216_E_01520Imported, BN1224_Panola_F_00840Imported, BN1224_PB1_B_04150Imported, BN1224_U1271_C_02560Imported, BN1224_UZG1_A_04270Imported, BN1224_Wien2_G_00510Imported, BN1224_YK41_BN_00520Imported, CWL029c_C_02550Imported
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)Imported
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 293CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 50Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
InterProiView protein in InterPro
IPR001095. Acetyl_CoA_COase_a_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011763. COA_CT_C.
PANTHERiPTHR42853. PTHR42853. 1 hit.
PfamiView protein in Pfam
PF03255. ACCA. 1 hit.
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00513. accA. 1 hit.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0F7XIR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMELLPHEK QVVEYEKAIA EFKEKNKKNS LLSSSEIQKL EKRLDKLKEK
60 70 80 90 100
IYSDLTPWER VQICRHPSRP RTVNYIEGMC EEFVELCGDR TFRDDPAVVG
110 120 130 140 150
GFVKIQGQRF VLIGQEKGCD TASRLHRNFG MLCPEGFRKA LRLGKLAEKF
160 170 180 190 200
GLPVVFLVDT PGAYPGLTAE ERGQGWAIAK NLFELSRLAT PVIIVVIGEG
210 220 230 240 250
CSGGALGMAV GDSVAMLEHS YYSVISPEGC ASILWKDPKK NSEAASMLKM
260 270 280 290 300
HGENLKQFGI IDTVIKEPIG GAHHDPALVY SNVREFIIQE WLRLKDLAIE
310 320
ELLEKRYEKF RSIGLYETTS ESGPEA
Length:326
Mass (Da):36,591
Last modified:July 22, 2015 - v1
Checksum:iE6DC7779856CED3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN846998 Genomic DNA. Translation: CRI38029.1.
LN847003 Genomic DNA. Translation: CRI40295.1.
LN847008 Genomic DNA. Translation: CRI41427.1.
LN847177 Genomic DNA. Translation: CRI43650.1.
LN847226 Genomic DNA. Translation: CRI45891.1.
LN847232 Genomic DNA. Translation: CRI47021.1.
LN847244 Genomic DNA. Translation: CRI49316.1.
LN847240 Genomic DNA. Translation: CRI50446.1.
LN847245 Genomic DNA. Translation: CRI51572.1.
LN847254 Genomic DNA. Translation: CRI52874.1.
LN849039 Genomic DNA. Translation: CRI73064.1.

Genome annotation databases

PATRICifig|83558.13.peg.440.

Similar proteinsi

Entry informationi

Entry nameiA0A0F7XIR7_CHLPN
AccessioniPrimary (citable) accession number: A0A0F7XIR7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: February 28, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)