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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
ORF Names:BN1224_GiD_A_09420Imported, BN1224_YK41_BY_00370Imported
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)Imported
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 35HelicalUniRule annotationAdd BLAST24
Transmembranei66 – 85HelicalUniRule annotationAdd BLAST20
Transmembranei91 – 109HelicalUniRule annotationAdd BLAST19
Transmembranei129 – 147HelicalUniRule annotationAdd BLAST19
Transmembranei167 – 185HelicalUniRule annotationAdd BLAST19
Transmembranei197 – 216HelicalUniRule annotationAdd BLAST20
Transmembranei228 – 245HelicalUniRule annotationAdd BLAST18
Transmembranei252 – 273HelicalUniRule annotationAdd BLAST22
Transmembranei279 – 298HelicalUniRule annotationAdd BLAST20
Transmembranei327 – 348HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

OMAiLMSPLHH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0F7WR30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPLIPMFLK QSLFFSLALT GMTTLVLTVS LGVPVMKWLK RKNYRDYIHK
60 70 80 90 100
EYCEKLEMLH KDKAEVPTGG GVLLFISLIA SLLVWLPWGK FSTWFFIILL
110 120 130 140 150
TCYAGLGWYD DRIKIKRKQG HGLKAKHKFM VQIAIAAFTL IALPYIYGST
160 170 180 190 200
EPLWTLKIPF MEGMLSLPFW LGKVFCLGLA LVAIIGTSNA VNLTDGLDGL
210 220 230 240 250
AAGTMSFAAL GFIFVALRSS TIPIAQDVAY VLAALVGACI GFLWYNGFPA
260 270 280 290 300
QLFMGDTGSL LLGGLLGSCA VMLRAECILV VIGGVFVAEA GSVILQVLSC
310 320 330 340
RLRKKRLFLC SPLHHHYEYQ GLPETKIVMR FWIFSFVCAG LGIAAVLWR
Length:349
Mass (Da):38,590
Last modified:July 22, 2015 - v1
Checksum:i6CAA9283C594A88B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN847008 Genomic DNA Translation: CRI41941.1
LN849050 Genomic DNA Translation: CRI73584.1
RefSeqiWP_010892232.1, NZ_LN846995.1

Genome annotation databases

PATRICifig|83558.18.peg.959

Similar proteinsi

Entry informationi

Entry nameiA0A0F7WR30_CHLPN
AccessioniPrimary (citable) accession number: A0A0F7WR30
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: March 28, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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