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Protein

Malate dehydrogenase

Gene

mdh

Organism
Spongiibacter sp. IMCC21906
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Binding sitei105NADUniRule annotation1
Binding sitei112NADUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Binding sitei162SubstrateUniRule annotation1
Active sitei187Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 17NADUniRule annotation7
Nucleotide bindingi129 – 131NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.37UniRule annotationSAAS annotation)
Gene namesi
Name:mdhUniRule annotation
ORF Names:IMCC21906_02339Imported
OrganismiSpongiibacter sp. IMCC21906Imported
Taxonomic identifieri1620392 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCellvibrionalesSpongiibacteraceaeSpongiibacter
Proteomesi
  • UP000035013 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 152Ldh_1_NInterPro annotationAdd BLAST148
Domaini156 – 322Ldh_1_CInterPro annotationAdd BLAST167

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

KOiK00024.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiView protein in PROSITE
PS00068. MDH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0F7M6Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQPVRVTVT GAAGQIGYAL LFRIASGSML GEDQPVILQL LDITPALDAL
60 70 80 90 100
QGVKMELEDC AFPLLAGVVC TDDPNVGFKD SDYALLVGAR PRGPGMERKD
110 120 130 140 150
LLEANAAIFS VQGKAIDQNA SKDIRVLVVG NPANTNALIT QRNAPSIPAR
160 170 180 190 200
NFTAMTRLDH NRAMTQIAQK TGKTVNDVTN MTIWGNHSAT QYPDLFNAKV
210 220 230 240 250
DGKTASDLVD QAWLESDFIP TVQQRGAAII KARGASSAAS AANAAIDHMR
260 270 280 290 300
SWALGTEGDD WVSMGVYSDG SYGIAEGLIY SFPCRCKDGQ WEIVQGVEVN
310 320
EFSRGKMDAT AQELTEERDG VKHLLP
Length:326
Mass (Da):35,041
Last modified:July 22, 2015 - v1
Checksum:i9EBFAE767037D3E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011477 Genomic DNA. Translation: AKH69999.1.
RefSeqiWP_047012293.1. NZ_CP011477.1.

Genome annotation databases

EnsemblBacteriaiAKH69999; AKH69999; IMCC21906_02339.
KEGGispoi:IMCC21906_02339.
PATRICifig|1620392.3.peg.2438.

Similar proteinsi

Entry informationi

Entry nameiA0A0F7M6Y7_9GAMM
AccessioniPrimary (citable) accession number: A0A0F7M6Y7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: November 22, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported