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Protein

Male determiner protein Nix

Gene

Nix

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Male determiner protein (M-factor) that controls male somatic sexual differentiation. Acts as a dominant factor that regulates the mRNA splicing of doublesex (dsx) or fruitless (fru) transcripts and promotes expression of male splice forms of dsx and fru.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • male sex determination Source: UniProtKB
  • male sex differentiation Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • regulation of mRNA splicing, via spliceosome Source: UniProtKB
  • RNA splicing Source: UniProtKB-KW

Keywordsi

Molecular functionRNA-binding
Biological processDifferentiation, mRNA processing, mRNA splicing, Sexual differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Male determiner protein Nix1 Publication
Gene namesi
Name:Nix1 Publication
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia

Pathology & Biotechi

Disruption phenotypei

Feminized males, which display features such as the absence of one or both gonocoxites and gonostyli, or antennae with fewer and shorter setae than normal males. Mosquitoes shifts the alternative splicing of dsx and fru toward their female isoforms.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004413191 – 288Male determiner protein NixAdd BLAST288

Expressioni

Developmental stagei

Male-specific expression. First detected 3 to 4 hours after oviposition, corresponding to the beginning of the syncytial blastoderm stage before sex is established.1 Publication

Structurei

3D structure databases

SMRiA0A0F6MY85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 94RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini108 – 179RRM 2PROSITE-ProRule annotationAdd BLAST72
Domaini205 – 282RRM 3PROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Repeat

Family and domain databases

InterProiView protein in InterPro
IPR035979. RBD_domain_sf.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 3 hits.
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0F6MY85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKKRNAEIN AEFDIIKKYC IYIGNIPFFA SKNDVVVKFA EYGETCNIYM
60 70 80 90 100
QSNKPHCDVK PAIVRYRSRK SVDKSLCLNN SKFGNTILIV LPLSLPYSRY
110 120 130 140 150
LLTYDTCIVV YINDKNSCKT SMAELYDEFQ KIGDIQNMFK TTNNMIYINF
160 170 180 190 200
ESEKSMQLSL ATKPFLINNN IFKIKKVERN INMCGLNSES QDFSTNLKKK
210 220 230 240 250
LLYNRSIGIF GLPSNATEER IAQIFSRFGD IQKITLICDV VGNSKQYGFI
260 270 280
YYKKRTSANA AKVIMDGENF EGNKISVRFV PEKKVFKN
Length:288
Mass (Da):33,163
Last modified:July 22, 2015 - v1
Checksum:iDBC83F3A863BE576
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF732822 mRNA. Translation: AHW46195.1.

Similar proteinsi

Entry informationi

Entry nameiNIX_AEDAE
AccessioniPrimary (citable) accession number: A0A0F6MY85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2017
Last sequence update: July 22, 2015
Last modified: October 25, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)