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Protein

Shikimate kinase

Gene

aroK

Organism
Burkholderia pseudomallei MSHR2543
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotationSAAS annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (BG16_5297), Phospho-2-dehydro-3-deoxyheptonate aldolase (BG16_1700)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA), 3-phosphoshikimate 1-carboxyvinyltransferase (aroA), 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21MagnesiumUniRule annotation1
Binding sitei39SubstrateUniRule annotation1
Binding sitei63SubstrateUniRule annotation1
Binding sitei85Substrate; via amide nitrogenUniRule annotation1
Binding sitei123ATPUniRule annotation1
Binding sitei142SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 22ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotation, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotationSAAS annotation (EC:2.7.1.71UniRule annotationSAAS annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
ORF Names:BG16_2113Imported
OrganismiBurkholderia pseudomallei MSHR2543Imported
Taxonomic identifieri1249472 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000032603 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0F6GEX2.
SMRiA0A0F6GEX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.UniRule annotation

Family and domain databases

CDDicd00464. SK. 1 hit.
HAMAPiMF_00109. Shikimate_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR031322. Shikimate/glucono_kinase.
IPR000623. Shikimate_kinase/TSH1.
IPR023000. Shikimate_kinase_CS.
PfamiView protein in Pfam
PF01202. SKI. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS01128. SHIKIMATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0F6GEX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQARDPHVNV IFVGLMGAGK TTVGRAVARR LDRPFFDSDH EIEARTGARI
60 70 80 90 100
PVIFELEGEA GFRDREAQMI AELTQRENIV LATGGGAILR PENRKLLHER
110 120 130 140 150
GLVVYLRANP HDLWLRTRKD KNRPLLQTDD PKAKLEALYE ARDPLYRECA
160 170 180
HFVIETGRPS VNGLVNMVLM QLEMAGIVAK PLQA
Length:184
Mass (Da):20,715
Last modified:June 24, 2015 - v1
Checksum:iBC2A5A026049D9B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009478 Genomic DNA. Translation: AJX77990.1.
RefSeqiWP_004535019.1. NZ_CP009478.1.

Genome annotation databases

EnsemblBacteriaiAJX77990; AJX77990; BG16_2113.
PATRICifig|1249472.3.peg.2468.

Similar proteinsi

Entry informationi

Entry nameiA0A0F6GEX2_BURPE
AccessioniPrimary (citable) accession number: A0A0F6GEX2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: September 27, 2017
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported