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Protein

Alanine racemase

Gene

alr

Organism
Mycobacterium lepromatosis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Active sitei273Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei321Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:MLPM_0375Imported
OrganismiMycobacterium lepromatosisImported
Taxonomic identifieri480418 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000053699 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44N6-(pyridoxal phosphate)lysineUniRule annotation1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini252 – 381Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0F4EVQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVIPISLKP GVLAEAVVDL GAIDYNVRVL REHAGRAQLM VVLKADAYGH
60 70 80 90 100
GATQVALAAL AAGAAELGVA TVDEALALRA DGISAPVLAW LHPPGIDFGP
110 120 130 140 150
ALLADVQIAV SSVRQLNELL DAVRRTGCTA TVTVKADTGL NRNGVVTDQY
160 170 180 190 200
PAMLTALQRA VVENAVRLRG LMSHLVYADQ PDNPSNDVQG KRFAALLAQA
210 220 230 240 250
RAQGLRFEVA HLSNSSATMC RPDLAYDLVR PGIAVYGLSP VPSRGDMGLI
260 270 280 290 300
PAMTVKCAVA LVKSIRAGEG VSYGNDWIAQ HDTNLALLPV GYADGVFRSL
310 320 330 340 350
GGRLDVLING KRRPGVGRIC MDQFVVDLGP GPIDVAEGDE AILFGPGASG
360 370 380
EPTAQDWADL LGTIHYEVVT SPRGRITRTY REAQTVDR
Length:388
Mass (Da):40,888
Last modified:June 24, 2015 - v1
Checksum:i86CF358D57C6F110
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JRPY01000019 Genomic DNA. Translation: KJX75715.1.
RefSeqiWP_045842429.1. NZ_JRPY01000019.1.

Genome annotation databases

EnsemblBacteriaiKJX75715; KJX75715; MLPM_0375.
PATRICifig|480418.6.peg.836.

Similar proteinsi

Entry informationi

Entry nameiA0A0F4EVQ3_9MYCO
AccessioniPrimary (citable) accession number: A0A0F4EVQ3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: September 27, 2017
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported