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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

NLO413_0699

Organism
Candidatus Neoehrlichia lotoris str. RAC413
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase
LigandPyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:NLO413_0699Imported
OrganismiCandidatus Neoehrlichia lotoris str. RAC413Imported
Taxonomic identifieri1359163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeCandidatus Neoehrlichia
Proteomesi
  • UP000033562 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73Lipoyl-bindingInterPro annotationAdd BLAST73
Domaini122 – 160Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST39

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom_sf.
IPR036625. E3-bd_dom_sf.
IPR006257. LAT1.
IPR004167. PSBD.
IPR011053. Single_hybrid_motif.
PfamiView protein in Pfam
PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiView protein in PROSITE
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS51826. PSBD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0F3NMM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALSPTMKS GSIVKWYKKE GDTVKAGEVI ADIETDKAVM EFEYADEDGI
60 70 80 90 100
IGIILSQEGS KNVPVNQLIA LVGIDDNDLQ LIKSYKQESL TNHPHVSSEP
110 120 130 140 150
NISTINTDNL ANNTRQQQTR IKASPLAKKI AYESSIDLST IKQGTGPYNR
160 170 180 190 200
IIKADVLEAI QNYQNCTRNN DVTSYFIEVS NTRQVIAHRL AESKQTIPHF
210 220 230 240 250
YLKIDCNVNN LLKLKAEVNN IDINNKITVN DFIIKATALS IKKFPSINVS
260 270 280 290 300
WINDKILQHT NIDVSFAVST DDGGLITPIV TNADKKSLSE ISHEAKALIA
310 320 330 340 350
KARNGRLQLK EFQGGSITIS NLGMFEIKEF IAIINPPQSC IMAVGQSKQQ
360 370 380 390
PVVIDSNIII ANVMTVTLSI DHRVIDGVLA AKFFNCFKNY IENPITMFI
Length:399
Mass (Da):44,191
Last modified:June 24, 2015 - v1
Checksum:iE7F770772E4B89F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LANX01000001 Genomic DNA. Translation: KJV69313.1.

Genome annotation databases

EnsemblBacteriaiKJV69313; KJV69313; NLO413_0699.
PATRICifig|1359163.3.peg.676.

Similar proteinsi

Entry informationi

Entry nameiA0A0F3NMM5_9RICK
AccessioniPrimary (citable) accession number: A0A0F3NMM5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: March 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported