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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptococcus cristatus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei615ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:TW70_01565Imported
OrganismiStreptococcus cristatusImported
Taxonomic identifieri45634 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000033683 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 163tRNA-synt_1gInterPro annotationAdd BLAST122
Domaini223 – 403tRNA-synt_1_2InterPro annotationAdd BLAST181
Domaini611 – 638tRNA-synt_1InterPro annotationAdd BLAST28
Domaini686 – 796Anticodon_1InterPro annotationAdd BLAST111

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi612 – 616"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0F2CKE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMATYNHKE IEPKWQKYWA EHHTFKTGTD KDKPNFYALD MFPYPSGAGL
60 70 80 90 100
HVGHPEGYTA TDILSRYKRA QGYNVLHPMG WDAFGLPAEQ YAMDTGNDPA
110 120 130 140 150
DFTAENIANF KRQINALGFS YDWDREVNTT DPNYYKWTQW IFTKLYEKGL
160 170 180 190 200
AYEAEVPVNW VEELGTAIAN EEVLPDGTSE RGGYPVVRKP MRQWMLKITA
210 220 230 240 250
YAERLLNDLE ELDWTESIKD MQRNWIGKST GANVTFKIKD TDKDFTVFTT
260 270 280 290 300
RPDTLFGATY AVLAPEHALV DAITSAEQAQ AVADYKHAAS LKSDLARTDL
310 320 330 340 350
AKEKTGVWTG AYAINPVNGK EIPIWIADYV LASYGTGAIM AVPAHDERDW
360 370 380 390 400
EFAKQFDLEI IPVLEGGNVA EAAYTEDGPH INSGFLDGLD KAAAIDKMVA
410 420 430 440 450
WLEAEGVGNE KVTYRLRDWL FSRQRYWGEP IPIIHWEDGT STAVPENELP
460 470 480 490 500
LVLPVTKDIR PSGTGESPLA NLTDWLEVTR EDGVKGRRET NTMPQWAGSS
510 520 530 540 550
WYYLRYIDPH NNEKLADEDL LKAWLPVDIY IGGAEHAVLH LLYARFWHKF
560 570 580 590 600
LYDIGVVPTK EPFQKLFNQG MILGTSYRDS RGALVATDKV EKRDGSFFNI
610 620 630 640 650
ETGEELEQAP AKMSKSLKNV VNPDDVVEQY GADTLRVYEM FMGPLDASIA
660 670 680 690 700
WSEEGLEGSR KFLDRVYRLI TSKEIVADNN GALDKVYNET VKSVTEQIEE
710 720 730 740 750
LKFNTAIAQL MIFVNAANKE EKLYVEYAKG FIQLLAPFAP HLAEELWQAV
760 770 780 790 800
AQTGESISYV AWPTYDESKL VEAEVEIVVQ IKGKVRAKLV VAKDLSREEL
810 820 830
QEIALADEKI KSEIAGKEIV KVISVPNKLV NIVVK
Length:835
Mass (Da):94,275
Last modified:June 24, 2015 - v1
Checksum:iA6D4593EAF5D6028
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JYGJ01000006 Genomic DNA. Translation: KJQ57826.1.

Genome annotation databases

EnsemblBacteriaiKJQ57826; KJQ57826; TW70_01565.
PATRICifig|45634.10.peg.1560.

Similar proteinsi

Entry informationi

Entry nameiA0A0F2CKE4_STRCR
AccessioniPrimary (citable) accession number: A0A0F2CKE4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: March 28, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported