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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotationSAAS annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotationSAAS annotation

Pathwayi: ppGpp biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA), Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA), Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA), Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA), Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA), Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA), Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA), Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00908; UER00885.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotationSAAS annotation (EC:3.6.1.40UniRule annotationSAAS annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
ORF Names:AGG09_13335Imported, B1727_31610Imported, B4U21_30835Imported, B4U22_31920Imported, B6J18_26470Imported, B8011_22885Imported, BCB67_21300Imported, BL124_0006325Imported, C0U44_08245Imported, CKJ89_14900Imported, CR230_09155Imported, CS372_01985Imported, CTI75_25620Imported, CWN54_22120Imported, CWQ24_27090Imported
OrganismiKlebsiella pneumoniaeImported
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000067608 Componenti: Chromosome
  • UP000234859 Componenti: Unassembled WGS sequence
  • UP000234597 Componenti: Unassembled WGS sequence
  • UP000230870 Componenti: Chromosome
  • UP000234635 Componenti: Unassembled WGS sequence
  • UP000215037 Componenti: Unassembled WGS sequence
  • UP000186691 Componenti: Unassembled WGS sequence
  • UP000196863 Componenti: Unassembled WGS sequence
  • UP000196744 Componenti: Unassembled WGS sequence
  • UP000218952 Componenti: Unassembled WGS sequence
  • UP000195917 Componenti: Unassembled WGS sequence
  • UP000232092 Componenti: Chromosome
  • UP000094167 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 300Ppx-GppAInterPro annotationAdd BLAST281

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01524.

Family and domain databases

HAMAPiMF_01550. GppA. 1 hit.
InterProiView protein in InterPro
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
IPR030673. PyroPPase_GppA_Ppx.
PfamiView protein in Pfam
PF02541. Ppx-GppA. 1 hit.
PIRSFiPIRSF001267. Pyrophosphatase_GppA_Ppx. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0E9YND6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTSLYAAI DLGSNSFHML VVREVAGSIQ TLSRIKRKVR LAAGLNSDNT
60 70 80 90 100
LSAEAMERGW QCLRLFAERL QDIPPTQIRV VATATLRLAV NAGEFLAKAQ
110 120 130 140 150
EILGTPVQVI SGEEEARLIY QGVAHTTGGA DQRLVVDIGG ASTELVTGTG
160 170 180 190 200
AQTTSLFSLS MGCVTWLERY FADRSLTKEN FDLAEAAARE VLLPVADVLR
210 220 230 240 250
YHGWKVCVGA SGTVQALQEI MMAQGMDERI TLAKLQQLKQ RAIQCGRLEE
260 270 280 290 300
LEIEGLTLER ALVFPSGLAI LIAIFSELNI QCMTLAGGAL REGLVYGMLH
310 320 330 340 350
LSVEQDIRSR TLRNIQRRFM IDTEQAQRVG GLASHLLSQL DGSWELDPLS
360 370 380 390 400
RDLLLSACAL HEIGLSVDFK RAPQHAAYLV NNLDLPGFTP AQKKLIATLL
410 420 430 440 450
LNQTNAIDLS SLHQQNAVPP RVAEHLCRLL RLAILFASRR RDDLLPAIQL
460 470 480 490
TAQDEQLTLI LPGNWLDEHP LGREMVDQEC QWQSYVHWIL RVASGDTLK
Length:499
Mass (Da):55,010
Last modified:June 24, 2015 - v1
Checksum:i1B905D136187C178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP013322 Genomic DNA. Translation: ALR25169.1.
CP024038 Genomic DNA. Translation: ATO22913.1.
CP024556 Genomic DNA. Translation: ATR65868.1.
CP025037 Genomic DNA. Translation: AUA53597.1.
MCNO01000054 Genomic DNA. Translation: ODN20124.1.
MPYG03000048 Genomic DNA. Translation: OSU25370.1.
NDCY01000115 Genomic DNA. Translation: OVH50508.1.
NBSB01002075 Genomic DNA. Translation: OWF97690.1.
NBSD01002249 Genomic DNA. Translation: OWG02037.1.
MZXR01000067 Genomic DNA. Translation: OXT19612.1.
NRQZ01000184 Genomic DNA. Translation: PAW15514.1.
PEGY01000001 Genomic DNA. Translation: PHY78182.1.
PKOM01000027 Genomic DNA. Translation: PLC30684.1.
NCOG01000033 Genomic DNA. Translation: PLG82546.1.
PIDW01001014 Genomic DNA. Translation: PLO77834.1.
RefSeqiWP_002883220.1. NZ_PJQK01000023.1.

Genome annotation databases

EnsemblBacteriaiALR25169; ALR25169; AGG09_13335.
ODN20124; ODN20124; BCB67_21300.
KEGGikpb:FH42_17760.
kpne:KU54_025850.
kpnu:LI86_25880.
PATRICifig|573.1346.peg.4506.

Similar proteinsi

Entry informationi

Entry nameiA0A0E9YND6_KLEPN
AccessioniPrimary (citable) accession number: A0A0E9YND6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: March 28, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported