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Protein

Malate dehydrogenase

Gene

mdh_2

Organism
Chlamydia trachomatis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93SubstrateUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Binding sitei106NADUniRule annotation1
Binding sitei113NADUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Active sitei188Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NADUniRule annotation7
Nucleotide bindingi130 – 132NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.37UniRule annotationSAAS annotation)
Gene namesi
Name:mdh_2Imported
Synonyms:mdhUniRule annotationImported
ORF Names:ERS015772_00243Imported, ERS082928_00088Imported, ERS177788_02175Imported
OrganismiChlamydia trachomatisImported
Taxonomic identifieri813 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000049904 Componenti: Unassembled WGS sequence
  • UP000038595 Componenti: Unassembled WGS sequence
  • UP000045537 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

SMRiA0A0E9CXI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 153Ldh_1_NInterPro annotationAdd BLAST147
Domaini158 – 321Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0E9CXI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSQTVSVAV TGGTGQIAYS FLFSLAHGDV FGLDCGIDLR IYDIPGTERA
60 70 80 90 100
LSGVRMELDD GAFPLLQRVQ VTTSLHDAFD GIDAAFLIGS VPRGPGMERR
110 120 130 140 150
DLLKKNGEIF ATQGKALNTT AKRDAKIFVV GNPVNTNCWI AMNHAPRLLR
160 170 180 190 200
KNFHAMLRLD QNRMHSMLSH RAEVPLSAVS QVVVWGNHSA KQVPDFTQAL
210 220 230 240 250
INDRPIAETI ADRDWLENIM VPSVQSRGSA VIEARGKSSA ASAARALAEA
260 270 280 290 300
ARSIYQPKEG EWFSSGVCSD HNPYGLPEDL IFGFPCRMLA TGEYEVIPRL
310 320
PWDAFIRGKM QISLDEILQE KASVSL
Length:326
Mass (Da):35,708
Last modified:June 24, 2015 - v1
Checksum:i2AE42107CBF08F1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CSTN01000002 Genomic DNA. Translation: CPR50322.1.
CTBL01000093 Genomic DNA. Translation: CQB86946.1.
CVNU01000001 Genomic DNA. Translation: CRH53768.1.
RefSeqiWP_009871729.1. NZ_CVNX01000001.1.

Genome annotation databases

EnsemblBacteriaiCPR50322; CPR50322; ERS015772_00243.
CQB86946; CQB86946; ERS177788_02175.
CRH53768; CRH53768; ERS082928_00088.
PATRICifig|813.32.peg.403.

Similar proteinsi

Entry informationi

Entry nameiA0A0E9CXI8_CHLTH
AccessioniPrimary (citable) accession number: A0A0E9CXI8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: November 22, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported