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Protein

Lysine--tRNA ligase

Gene

lysS_2

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 3 Mg2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi415Magnesium 1UniRule annotation1
Metal bindingi422Magnesium 1UniRule annotation1
Metal bindingi422Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysS_2Imported
Synonyms:lysSUniRule annotationImported, lysS_1Imported
ORF Names:C0082_19695Imported, C0083_19675Imported, C0084_19690Imported, C0085_19680Imported, C0086_19680Imported, C0087_19670Imported, C0089_19675Imported, C0090_19690Imported, C0091_19675Imported, C0092_19680Imported, C0093_19670Imported, C0094_19670Imported, C0095_19705Imported, C0096_19680Imported, C0097_19675Imported, CRX58_10170Imported, ERS007657_01228Imported, ERS007665_01671Imported, ERS007670_02894Imported, ERS007672_02986Imported, ERS007703_03055Imported, ERS023446_03820Imported, ERS024213_00381Imported, ERS024276_02257Imported, ERS027644_01504Imported, ERS027652_00531Imported, ERS027654_00970Imported, ERS027656_01091Imported, ERS027661_02841Imported, ERS027666_02607Imported, ERS031537_01275Imported, ERS124361_02031Imported, SAMEA2682864_02664Imported, SAMEA2683035_00697Imported
OrganismiMycobacterium tuberculosisImported
Taxonomic identifieri1773 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000235532 Componenti: Chromosome
  • UP000049299 Componenti: Unassembled WGS sequence
  • UP000222967 Componenti: Unassembled WGS sequence
  • UP000235605 Componenti: Chromosome
  • UP000049861 Componenti: Unassembled WGS sequence
  • UP000046932 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000235433 Componenti: Chromosome
  • UP000235539 Componenti: Chromosome
  • UP000049139 Componenti: Unassembled WGS sequence
  • UP000050143 Componenti: Unassembled WGS sequence
  • UP000235486 Componenti: Chromosome
  • UP000049498 Componenti: Unassembled WGS sequence
  • UP000047075 Componenti: Unassembled WGS sequence
  • UP000235544 Componenti: Chromosome
  • UP000235517 Componenti: Chromosome
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000235825 Componenti: Chromosome
  • UP000183655 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000235664 Componenti: Chromosome
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000049258 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000235436 Componenti: Chromosome
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000235535 Componenti: Chromosome
  • UP000235424 Componenti: Chromosome
  • UP000235431 Componenti: Chromosome
  • UP000235832 Componenti: Chromosome
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000050038 Componenti: Unassembled WGS sequence
  • UP000235600 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 502AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST324

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_00252. Lys_tRNA_synth_class2. 1 hit.
InterProiView protein in InterPro
IPR004364. aa-tRNA-synt_II.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
PfamiView protein in Pfam
PF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS50862. AA_TRNA_LIGASE_II. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0E8V7T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAADTAEDL PEQFRIRRDK RARLLAQGRD PYPVAVPRTH TLAEVRAAHP
60 70 80 90 100
DLPIDTATED IVGVAGRVIF ARNSGKLCFA TLQDGDGTQL QVMISLDKVG
110 120 130 140 150
QAALDAWKAD VDLGDIVYVH GAVISSRRGE LSVLADCWRI AAKSLRPLPV
160 170 180 190 200
AHKEMSEESR VRQRYVDLIV RPEARAVARL RIAVVRAIRT ALQRRGFLEV
210 220 230 240 250
ETPVLQTLAG GAAARPFATH SNALDIDLYL RIAPELFLKR CIVGGFDKVF
260 270 280 290 300
ELNRVFRNEG ADSTHSPEFS MLETYQTYGT YDDSAVVTRE LIQEVADEAI
310 320 330 340 350
GTRQLPLPDG SVYDIDGEWA TIQMYPSLSV ALGEEITPQT TVDRLRGIAD
360 370 380 390 400
SLGLEKDPAI HDNRGFGHGK LIEELWERTV GKSLSAPTFV KDFPVQTTPL
410 420 430 440 450
TRQHRSIPGV TEKWDLYLRG IELATGYSEL SDPVVQRERF ADQARAAAAG
460 470 480 490 500
DDEAMVLDED FLAALEYGMP PCTGTGMGID RLLMSLTGLS IRETVLFPIV

RPHSN
Length:505
Mass (Da):55,709
Last modified:June 24, 2015 - v1
Checksum:iE12FFC867152740C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025593 Genomic DNA. Translation: AUP53113.1.
CP025594 Genomic DNA. Translation: AUP57255.1.
CP025595 Genomic DNA. Translation: AUP61391.1.
CP025596 Genomic DNA. Translation: AUP65515.1.
CP025597 Genomic DNA. Translation: AUP69661.1.
CP025598 Genomic DNA. Translation: AUP73804.1.
CP025599 Genomic DNA. Translation: AUP85082.1.
CP025601 Genomic DNA. Translation: AUP93351.1.
CP025602 Genomic DNA. Translation: AUP97481.1.
CP025603 Genomic DNA. Translation: AUQ01606.1.
CP025604 Genomic DNA. Translation: AUQ05759.1.
CP025605 Genomic DNA. Translation: AUQ09893.1.
CP025606 Genomic DNA. Translation: AUQ14021.1.
CP025607 Genomic DNA. Translation: AUQ18153.1.
CP025608 Genomic DNA. Translation: AUQ22281.1.
CGCX01000354 Genomic DNA. Translation: CFR73860.1.
CNDE01000052 Genomic DNA. Translation: CKO39198.1.
CNCN01000576 Genomic DNA. Translation: CKO97835.1.
CNFQ01000068 Genomic DNA. Translation: CKR01934.1.
CNFR01000139 Genomic DNA. Translation: CKR26174.1.
CNFV01000129 Genomic DNA. Translation: CKR34422.1.
CNFW01000218 Genomic DNA. Translation: CKR54042.1.
CNFU01000654 Genomic DNA. Translation: CKS27269.1.
CNGG01000530 Genomic DNA. Translation: CKT34853.1.
CNIS01000158 Genomic DNA. Translation: CKU79802.1.
CHDS01000033 Genomic DNA. Translation: CNG83462.1.
CQGE01000148 Genomic DNA. Translation: CNN53772.1.
CQPW01000290 Genomic DNA. Translation: CNU81207.1.
CQPL01000691 Genomic DNA. Translation: CNV29983.1.
CHEE01000618 Genomic DNA. Translation: COW08502.1.
CSAE01000382 Genomic DNA. Translation: COW20578.1.
PDLG01000001 Genomic DNA. Translation: PHG96389.1.
FPTZ01000003 Genomic DNA. Translation: SGH25785.1.
FPXX01000016 Genomic DNA. Translation: SGM54587.1.
RefSeqiWP_003419514.1. NZ_PDLG01000001.1.

Genome annotation databases

EnsemblBacteriaiAMC48112; AMC48112; RN05_3836.
CFR73860; CFR73860; ERS007657_01228.
CKO39198; CKO39198; ERS024213_00381.
CKO97835; CKO97835; ERS024276_02257.
CKR01934; CKR01934; ERS027652_00531.
CKR26174; CKR26174; ERS027654_00970.
CKR34422; CKR34422; ERS027656_01091.
CKR54042; CKR54042; ERS027644_01504.
CKS27269; CKS27269; ERS027661_02841.
CKT34853; CKT34853; ERS027666_02607.
CKU79802; CKU79802; ERS031537_01275.
CNG83462; CNG83462; ERS124361_02031.
CNN53772; CNN53772; ERS023446_03820.
CNU81207; CNU81207; ERS007665_01671.
CNV29983; CNV29983; ERS007670_02894.
CNZ16100; CNZ16100; ERS013471_03690.
COW08502; COW08502; ERS007672_02986.
COW20578; COW20578; ERS007703_03055.
PATRICifig|1773.206.peg.3944.

Similar proteinsi

Entry informationi

Entry nameiA0A0E8V7T2_MYCTX
AccessioniPrimary (citable) accession number: A0A0E8V7T2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: March 28, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported