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Protein

GTP cyclohydrolase-2

Gene

ribA

Organism
Pasteurella multocida subsp. multocida OH4807
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.UniRule annotation

Catalytic activityi

GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: riboflavin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. GTP cyclohydrolase-2 (ribA)
  2. Riboflavin biosynthesis protein RibD (I926_01445)
  3. Riboflavin biosynthesis protein RibD (I926_01445)
  4. no protein annotated in this organism
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Zinc; catalyticUniRule annotation1
Metal bindingi67Zinc; catalyticUniRule annotation1
Metal bindingi69Zinc; catalyticUniRule annotation1
Binding sitei72GTPUniRule annotation1
Binding sitei116GTPUniRule annotation1
Active sitei128Proton acceptorUniRule annotation1
Active sitei130NucleophileUniRule annotation1
Binding sitei151GTPUniRule annotation1
Binding sitei156GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 55GTPUniRule annotation5
Nucleotide bindingi94 – 96GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processRiboflavin biosynthesisUniRule annotationSAAS annotation
LigandGTP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00275; UER00400

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase-2UniRule annotation (EC:3.5.4.25UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IIUniRule annotation
Gene namesi
Name:ribAUniRule annotationImported
ORF Names:I926_01535Imported
OrganismiPasteurella multocida subsp. multocida OH4807Imported
Taxonomic identifieri1304873 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000033064 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 171GTP_cyclohydro2InterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the GTP cyclohydrolase II family.UniRule annotation

Family and domain databases

CDDicd00641 GTP_cyclohydro2, 1 hit
Gene3Di3.40.50.10990, 1 hit
HAMAPiMF_00179 RibA, 1 hit
InterProiView protein in InterPro
IPR032677 GTP_cyclohydro_II
IPR000926 RibA
IPR036144 RibA-like_sf
PfamiView protein in Pfam
PF00925 GTP_cyclohydro2, 1 hit
SUPFAMiSSF142695 SSF142695, 1 hit
TIGRFAMsiTIGR00505 ribA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E3ZNH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIQRVTEA NLPTEFGVFK IVGFEFPDTK KEHVALVLGD IENTDEPILA
60 70 80 90 100
RIHSECLTGD ALHSLKCDCG FQLAAALRQI SEAGRGVLLY HREEGRGIGL
110 120 130 140 150
INKIRAYALQ DQGMDTIEAN LALGFAADER NFEVCADMFD LLGVKEIRLL
160 170 180 190 200
TNNPNKIETM RKSGINIVER VALNVGENRY NTEYLDTKAK KMGHFIVHNQ
210
QKHLLECPYC SEEVPTQNK
Length:219
Mass (Da):24,573
Last modified:June 24, 2015 - v1
Checksum:i4557C0F0A1CE2C35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP004391 Genomic DNA Translation: AKD37637.1
RefSeqiWP_046338608.1, NZ_CP004391.1

Genome annotation databases

EnsemblBacteriaiAKD37637; AKD37637; I926_01535
PATRICifig|1304873.3.peg.314

Similar proteinsi

Entry informationi

Entry nameiA0A0E3ZNH7_PASMD
AccessioniPrimary (citable) accession number: A0A0E3ZNH7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: June 20, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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