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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptococcus varani
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei675ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:BN1356_00193Imported
OrganismiStreptococcus varaniImported
Taxonomic identifieri1608583 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000198604 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 223tRNA-synt_1gInterPro annotationAdd BLAST122
Domaini283 – 463tRNA-synt_1_2InterPro annotationAdd BLAST181
Domaini476 – 633tRNA-synt_1InterPro annotationAdd BLAST158
Domaini671 – 698tRNA-synt_1InterPro annotationAdd BLAST28
Domaini746 – 856Anticodon_1InterPro annotationAdd BLAST111

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi672 – 676"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0E3WEK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGLKSSWE INKSRMLASQ SSGFSQSIKF DCENLSRLDE GASRESKMLD
60 70 80 90 100
LLLIFYGLGI LIMTTYNHKE VEPKWQKHWA DHHTFKTGTD ASKPKFYALD
110 120 130 140 150
MFPYPSGAGL HVGHPEGYTA TDILSRYKRA NGYNVLHPMG WDAFGLPAEQ
160 170 180 190 200
YAMDTGNDPA DFTAENIATF KRQINALGFS YDWDREINTT DPNYYKWTQW
210 220 230 240 250
IFTKLYEKGL AYEAEVPVNW VEELGTAIAN EEVLPDGTSE RGGYPVVRKP
260 270 280 290 300
MRQWMLKITT YAERLLQDLE EVDWPESIKD MQRNWIGKST GANVTFKIKD
310 320 330 340 350
TDKNFTVFTT RPDTLFGATY AVLAPEHALV DAITSADQAD AVAEYKRQAS
360 370 380 390 400
LKSDLARTDL AKEKTGVWTG AYAINPVNGK EMPIWIADYV LASYGTGAIM
410 420 430 440 450
AVPAHDERDW EFAKAFNLEI LPVLEGGNVD EAAYTEDGAH INSDFLDGLD
460 470 480 490 500
KADAIAKMVA WLEEEGVGTE KVTYRLRDWL FSRQRYWGEP IPIIHWEDGT
510 520 530 540 550
STAVPESELP LVLPVTKDIR PSGTGESPLA NLTDWLEVIR EDRVKGRRET
560 570 580 590 600
NTMPQWAGSS WYYLRYIDPH NTEKLADEEL LKQWLPVDIY VGGAEHAVLH
610 620 630 640 650
LLYARFWHKF LYDIGVVPTK EPFQKLFNQG MILGTSYRDG RGALVATDKV
660 670 680 690 700
EKRDGSFFHV ETGEELEQAP AKMSKSLKNV VNPDDVIVQY GADTLRVYEM
710 720 730 740 750
FMGPLDASIA WSEEGLEGSR KFLDRVYRLI STKELTTENK GNLDKVYNET
760 770 780 790 800
VKAVSEQIEG MKFNTAIAQL MIFVNSANKE DKLFVDYAKG FIQLLAPFAP
810 820 830 840 850
HLGEELWQMV TGSTESISHV AWPTWDESKL VEAEVEIVVQ IKGKVKAKLM
860 870 880 890
VPKDASREEL EAIAMADAKV QAEIAGKDIV KVIAVPNKLV NIVVK
Length:895
Mass (Da):100,976
Last modified:June 24, 2015 - v1
Checksum:iABC4C77211E64B2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CTEN01000001 Genomic DNA. Translation: CQR23825.1.

Similar proteinsi

Entry informationi

Entry nameiA0A0E3WEK2_9STRE
AccessioniPrimary (citable) accession number: A0A0E3WEK2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: March 28, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported