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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Verrucomicrobia bacterium IMCC26134
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi265Magnesium or manganese 1UniRule annotation1
Metal bindingi278Magnesium or manganese 1UniRule annotation1
Metal bindingi278Magnesium or manganese 2UniRule annotation1
Metal bindingi280Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
ORF Names:IMCC26134_02620Imported
OrganismiVerrucomicrobia bacterium IMCC26134Imported
Taxonomic identifieri1637999 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaunclassified Verrucomicrobia
Proteomesi
  • UP000033046 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 311ATP-graspInterPro annotationAdd BLAST196

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom_sf.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 2 hits.
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0E3UHH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVILSATSA LSRATGLSPR ITVLAGGVSS EREVSLGSGA AAAQALARLW
60 70 80 90 100
PTRLIDVTAP DLPLGLDPDR DVVFSTLHGT FGEDGGMQAL LDAACIVYAG
110 120 130 140 150
CGTASSALTM DKAATKRAAA QVGVNVAADL TFSAATRPEV GEVIAALGER
160 170 180 190 200
VVFKPNDQGS SVGLALPEGR EEIGSALAVI SAGNWIAEPR LVGRELSVGV
210 220 230 240 250
LGGKAMGVVE IRPRSGVYDF ASKYTKGATE YLAPAPLEAE VAMAVQRAAE
260 270 280 290 300
SAFAACGCRD YARVDFILIS ENEFYLLEIN TLPGMKETSL LPMSARCAGL
310 320
DFTALVRELV VPAVNRLQAA RFLANK
Length:326
Mass (Da):33,829
Last modified:June 24, 2015 - v1
Checksum:iC4392913A6DA1D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011265 Genomic DNA. Translation: AKC81946.1.
RefSeqiWP_046297336.1. NZ_CP011265.1.

Genome annotation databases

EnsemblBacteriaiAKC81946; AKC81946; IMCC26134_02620.
KEGGivba:IMCC26134_02620.
PATRICifig|1637999.3.peg.559.

Similar proteinsi

Entry informationi

Entry nameiA0A0E3UHH8_9BACT
AccessioniPrimary (citable) accession number: A0A0E3UHH8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: November 22, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported