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Protein

Brain-derived neurotrophic factor

Gene

BDNF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-derived neurotrophic factorUniRule annotation
Short name:
BDNFUniRule annotation
Gene namesi
Name:BDNFImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000176697.18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18UniRule annotationAdd BLAST18
ChainiPRO_501420326419 – 247Brain-derived neurotrophic factorUniRule annotationAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi141 ↔ 208UniRule annotation
Disulfide bondi186 ↔ 237UniRule annotation
Disulfide bondi196 ↔ 239UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000176697

Interactioni

Subunit structurei

Monomers and homodimers. Binds to NTRK2/TRKB.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 240NGFInterPro annotationAdd BLAST108

Sequence similaritiesi

Belongs to the NGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

KOiK04355

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR020430 Brain-der_neurotrophic_factor
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF3 PTHR11589:SF3, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01912 BDNFACTOR
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E3SU01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK
60 70 80 90 100
AGSRGLTSLA DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV
110 120 130 140 150
PLEPPLLFLL EEYKNYLDAA NMSMRVRRHS DPARRGELSV CDSISEWVTA
160 170 180 190 200
ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY FYETKCNPMG YTKEGCRGID
210 220 230 240
KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT LTIKRGR
Length:247
Mass (Da):27,818
Last modified:June 24, 2015 - v1
Checksum:i0A60488254722A99
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei247Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KP229412 mRNA Translation: AKB90516.1
KU177943 mRNA Translation: ALQ33401.1
RefSeqiNP_001137277.1, NM_001143805.1
NP_001137278.1, NM_001143806.1
NP_001137279.1, NM_001143807.1
NP_001137280.1, NM_001143808.1
NP_001137283.1, NM_001143811.1
NP_001137284.1, NM_001143812.1
NP_001137285.1, NM_001143813.1
NP_001137286.1, NM_001143814.1
NP_001137288.1, NM_001143816.1
NP_001700.2, NM_001709.4
NP_733928.1, NM_170732.4
NP_733929.1, NM_170733.3
NP_733931.1, NM_170735.5
UniGeneiHs.502182

Genome annotation databases

GeneIDi627
KEGGihsa:627

Similar proteinsi

Entry informationi

Entry nameiA0A0E3SU01_HUMAN
AccessioniPrimary (citable) accession number: A0A0E3SU01
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: April 25, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health