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Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase

Gene

aroF

Organism
Escherichia coli 1303
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (aroH), Phospho-2-dehydro-3-deoxyheptonate aldolase (aroF), Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroD)
  4. Quinate/shikimate dehydrogenase (ydiB), Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase 2 (aroL), Shikimate kinase 1 (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00053; UER00084.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolaseUniRule annotation (EC:2.5.1.54UniRule annotation)
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthaseUniRule annotation
DAHP synthaseUniRule annotation
Phospho-2-keto-3-deoxyheptonate aldolaseUniRule annotation
Gene namesi
Name:aroFImported
ORF Names:EC1303_c27540Imported
OrganismiEscherichia coli 1303Imported
Taxonomic identifieri745156 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000031758 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA0A0E1M4W6.
SMRiA0A0E1M4W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 340DAHP_synth_1InterPro annotationAdd BLAST302

Sequence similaritiesi

Belongs to the class-I DAHP synthase family.UniRule annotation

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
PANTHERiPTHR21225. PTHR21225. 1 hit.
PfamiView protein in Pfam
PF00793. DAHP_synth_1. 1 hit.
PIRSFiPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsiTIGR00034. aroFGH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0E1M4W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKDALNNVH ITDEQVLMTP EQLKAAFPLS LQQEAQIADS RKSISDIIAG
60 70 80 90 100
RDPRLLVVCG PCSIHDPETA LEYARRFKAL AAEVSDSLYL VMRVYFEKPR
110 120 130 140 150
TTVGWKGLIN DPHMDGSFDV EAGLQIARKL LLELVNMGLP LATEALDPNS
160 170 180 190 200
PQYLGDLFSW SAIGARTTES QTHREMASGL SMPVGFKNGT DGSLATAINA
210 220 230 240 250
MRAAAQPHRF VGINQAGQVA LLQTQGNPDG HVILRGGKAP NYSPADVAQC
260 270 280 290 300
EKEMEQAGLR PSLMVDCSHG NSNKDYRRQP AVAESVVAQI KDGNRSIIGL
310 320 330 340 350
MIESNIHEGN QSSEQPRSEM KYGVSVTDAC ISWEMTDALL REIHQDLNGQ

LTARVA
Length:356
Mass (Da):38,804
Last modified:May 27, 2015 - v1
Checksum:iA675537531FBC37D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009166 Genomic DNA. Translation: AJF57454.1.
RefSeqiWP_001168037.1. NZ_CP009166.1.

Genome annotation databases

EnsemblBacteriaiAJF57454; AJF57454; EC1303_c27540.

Similar proteinsi

Entry informationi

Entry nameiA0A0E1M4W6_ECOLX
AccessioniPrimary (citable) accession number: A0A0E1M4W6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: June 7, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported