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Protein

Acetylornithine deacetylase

Gene

argE

Organism
Klebsiella pneumoniae 30660/NJST258_1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Co2+SAAS annotation
  • glutathioneUniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetylornithine deacetylase (argE)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi118Cobalt or zinc 1UniRule annotation1
Active sitei120UniRule annotation1
Metal bindingi150Cobalt or zinc 1UniRule annotation1
Metal bindingi150Cobalt or zinc 2UniRule annotation1
Active sitei182UniRule annotation1
Metal bindingi183Cobalt or zinc 2UniRule annotation1
Metal bindingi207Cobalt or zinc 1UniRule annotation1
Metal bindingi393Cobalt or zinc 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandCobaltUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylaseUniRule annotation (EC:3.5.1.16UniRule annotation)
Short name:
AOUniRule annotation
Short name:
AcetylornithinaseUniRule annotation
Alternative name(s):
N-acetylornithinaseUniRule annotation
Short name:
NAOUniRule annotation
Gene namesi
Name:argEUniRule annotation
ORF Names:KPNJ1_05350Imported
OrganismiKlebsiella pneumoniae 30660/NJST258_1Imported
Taxonomic identifieri1420012 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000019583 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini216 – 325M20_dimerInterPro annotationAdd BLAST110

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01438

Family and domain databases

CDDicd03894 M20_ArgE, 1 hit
HAMAPiMF_01108 ArgE, 1 hit
InterProiView protein in InterPro
IPR010169 AcOrn-deacetyl
IPR001261 ArgE/DapE_CS
IPR036264 Bact_exopeptidase_dim_dom
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PANTHERiPTHR43808:SF1 PTHR43808:SF1, 1 hit
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
SUPFAMiSSF55031 SSF55031, 1 hit
TIGRFAMsiTIGR01892 AcOrn-deacetyl, 1 hit
PROSITEiView protein in PROSITE
PS00758 ARGE_DAPE_CPG2_1, 1 hit
PS00759 ARGE_DAPE_CPG2_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E1CRL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAHLLTFDG FSYAQRYCIF IHNKCMNIDT ITTQGVSTMK NNLPPFIEIY
60 70 80 90 100
RALIATPSIS ATEEALDQSN ESLINLLAGW FRDLGFNVEV QPVPDTRHKF
110 120 130 140 150
NLLASTGHGA GGLLLAGHTD TVPFDDGRWT RDPFTLTEHD NKLYGLGTAD
160 170 180 190 200
MKGFFAFILD ALRDVDVTTL KKPLYILATA DEETSMAGAR YFAETTQLRP
210 220 230 240 250
DCAIIGEPTS LQPIRAHKGH MSNAIRIQGQ SGHSSDPARG VNAIELMHDA
260 270 280 290 300
IGRIMQLRDL LKERYHFEAF TVPYPTLNLG AIHGGDASNR ICACCELHMD
310 320 330 340 350
IRPLPGMTLN DLNGLLGEAL APVSERWPGR LTFSELHPPI PGYECPPDHK
360 370 380 390 400
LVQVVEKLLG AQTDVVNYCT EAPFIQTLCP TLVLGPGSIN QAHQPDEFLE
410 420
TRFIKPTREL ISQVVHHFCW H
Length:421
Mass (Da):46,737
Last modified:May 27, 2015 - v1
Checksum:i48D386391DA357EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006923 Genomic DNA Translation: AHM87738.1

Genome annotation databases

EnsemblBacteriaiAHM87738; AHM87738; KPNJ1_05350
KEGGikpa:KPNJ1_05350
PATRICifig|1420012.3.peg.4986

Similar proteinsi

Entry informationi

Entry nameiA0A0E1CRL0_KLEPN
AccessioniPrimary (citable) accession number: A0A0E1CRL0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: November 22, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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