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Protein
Submitted name:

Transcription factor 7-like 2

Gene

TCF7L2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi332 – 400HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor 7-like 2Imported
Gene namesi
Name:TCF7L2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148737.15.
HGNCiHGNC:11641. TCF7L2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148737.

Expressioni

Gene expression databases

BgeeiENSG00000148737.
ExpressionAtlasiA0A0D9SGH8. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0D9SGH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini332 – 400HMG boxInterPro annotationAdd BLAST69

Phylogenomic databases

GeneTreeiENSGT00390000009964.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProiView protein in InterPro
IPR027397. Catenin_binding_dom_sf.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
IPR024940. TCF/LEF.
IPR028773. TCF7L.
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF25. PTHR10373:SF25. 1 hit.
PfamiView protein in Pfam
PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0D9SGH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN
60 70 80 90 100
ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY
110 120 130 140 150
PGYPFIMIPD LTSPYLPNGS LSPTARTYLQ MKWPLLDVQA GSLQSRQALK
160 170 180 190 200
DARSPSPAHI VSNKVPVVQH PHHVHPLTPL ITYSNEHFTP GNPPPHLPAD
210 220 230 240 250
VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWLVPQ QGQPVYPITT
260 270 280 290 300
GGFRHPYPTA LTVNASMSSF LSSRFPPHMV PPHHTLHTTG IPHPAIVTPT
310 320 330 340 350
VKQESSQSDV GSLHSSKHQD SKKEEEKKKP HIKKPLNAFM LYMKEMRAKV
360 370 380 390 400
VAECTLKESA AINQILGRRW HALSREEQAK YYELARKERQ LHMQLYPGWS
410 420 430 440 450
ARDNYGKKKK RKRDKQPGET NDANTPKKCR ALFGLDRQTL WCKPCRRKKK
460 470 480 490 500
CVRYIQGEGS CLSPPSSDGS LLDSPPPSPN LLGSPPRDAK SQTEQTQPLS
510 520 530 540 550
LSLKPDPLAH LSMMPPPPAL LLAEATHKAS ALCPNGALDL PPAALQPAAP
560 570 580
SSSIAQPSTS SLHSHSSLAG TQPQPLSLVT KSLE
Length:584
Mass (Da):63,987
Last modified:May 27, 2015 - v1
Checksum:i587235CA33EFBD25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135792 Genomic DNA. No translation available.
AL158212 Genomic DNA. No translation available.
AL445486 Genomic DNA. No translation available.
AL451084 Genomic DNA. No translation available.
RefSeqiXP_005270146.1. XM_005270089.1.
UniGeneiHs.593995.

Genome annotation databases

EnsembliENST00000629706; ENSP00000487507; ENSG00000148737.
GeneIDi6934.

Similar proteinsi

Entry informationi

Entry nameiA0A0D9SGH8_HUMAN
AccessioniPrimary (citable) accession number: A0A0D9SGH8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: November 22, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported