CASP3

Functionⁱ

GO - Molecular functionⁱ

aspartic-type endopeptidase activity Source: Ensembl
cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl
cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

B cell homeostasis Source: Ensembl
cell fate commitment Source: Ensembl
cellular response to DNA damage stimulus Source: Ensembl
cellular response to staurosporine Source: Ensembl
erythrocyte differentiation Source: Ensembl
glial cell apoptotic process Source: Ensembl
heart development Source: Ensembl
intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
keratinocyte differentiation Source: Ensembl
negative regulation of activated T cell proliferation Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of B cell proliferation Source: Ensembl
negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
neuron apoptotic process Source: Ensembl
neurotrophin TRK receptor signaling pathway Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
protein processing Source: Ensembl
response to UV Source: Ensembl
response to wounding Source: Ensembl
sensory perception of sound Source: Ensembl
T cell homeostasis Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol proteaseSAAS annotation

Molecular function

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Uncharacterized proteinImported
Gene namesⁱ	Name:CASP3Imported
Organismⁱ	Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)Imported
Taxonomic identifierⁱ	60711 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Chlorocebus
Proteomesⁱ	UP000029965 Componentⁱ: Chromosome 7

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol Source: Ensembl
nucleus Source: Ensembl

Complete GO annotation...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	43 – 167	CASPASE_P20InterPro annotationAdd BLAST		125
Domainⁱ	183 – 277	CASPASE_P10InterPro annotationAdd BLAST		95

Sequence similaritiesⁱ

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118912.
KEGG Orthology (KO) More...KOⁱ	K02187.
OMAⁱ	NHEFFTI.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032. CASc. 1 hit.
InterProⁱ	View protein in InterPro IPR029030. Caspase-like_dom. IPR015470. Caspase_3. IPR033139. Caspase_cys_AS. IPR016129. Caspase_his_AS. IPR002138. Pept_C14_p10. IPR001309. Pept_C14_p20. IPR015917. Pept_C14A.
PANTHERⁱ	PTHR10454:SF178. PTHR10454:SF178. 1 hit.
PRINTSⁱ	PR00376. IL1BCENZYME.
SMARTⁱ	View protein in SMART SM00115. CASc. 1 hit.
SUPFAMⁱ	SSF52129. SSF52129. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A0D9S2F1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MENTENSVDS KSIKSLEPKI IHGSKSVDSG ISLDNSYKMD YPEMGLCIII 
        60         70         80         90        100
NNKNFHKSTG MASRSGTDVD AANLRETFIN LKYEVRNKND LTREEIVELM 
       110        120        130        140        150
RNVSKEDHSK RSSFVCVLLS HGEEGIIFGT NGPLDLKKIT SFFRGDCCRS 
       160        170        180        190        200
LTGKPKLFII QACRGTELDC GIETDSGVED DMACHKIPVE ADFLYAYSTA 
       210        220        230        240        250
PGYYSWRNSK DGSWFIQSLC AMLKQYADKL EFMHILTRVN RKVATEFESF 
       260        270 
SLDATFHAKK QIPCIVSMLT KELYFYH

Length:277

Mass (Da):31,388

Last modified:May 27, 2015 - v1

Checksum:ⁱ8EEB420E130D0301

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AQIB01017968 Genomic DNA. No translation available. AQIB01017969 Genomic DNA. No translation available. AQIB01017970 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_007998581.1. XM_008000390.1. XP_007998582.1. XM_008000391.1. XP_007998583.1. XM_008000392.1.

Genome annotation databases

Ensemblⁱ	ENSCSAT00000001027; ENSCSAP00000015040; ENSCSAG00000003002.
GeneIDⁱ	103236614.
KEGGⁱ	csab:103236614.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AQIB01017968 Genomic DNA. No translation available. AQIB01017969 Genomic DNA. No translation available. AQIB01017970 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_007998581.1. XM_008000390.1. XP_007998582.1. XM_008000391.1. XP_007998583.1. XM_008000392.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSCSAT00000001027; ENSCSAP00000015040; ENSCSAG00000003002.
GeneIDⁱ	103236614.
KEGGⁱ	csab:103236614.

Organism-specific databases

CTDⁱ	836.

CTDⁱ

836.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118912.
KEGG Orthology (KO) More...KOⁱ	K02187.
OMAⁱ	NHEFFTI.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032. CASc. 1 hit.
InterProⁱ	View protein in InterPro IPR029030. Caspase-like_dom. IPR015470. Caspase_3. IPR033139. Caspase_cys_AS. IPR016129. Caspase_his_AS. IPR002138. Pept_C14_p10. IPR001309. Pept_C14_p20. IPR015917. Pept_C14A.
PANTHERⁱ	PTHR10454:SF178. PTHR10454:SF178. 1 hit.
PRINTSⁱ	PR00376. IL1BCENZYME.
SMARTⁱ	View protein in SMART SM00115. CASc. 1 hit.
SUPFAMⁱ	SSF52129. SSF52129. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A0D9S2F1_CHLSB
Accessionⁱ	A0A0D9S2F1Primary (citable) accession number: A0A0D9S2F1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 27, 2015
	Last sequence update:	May 27, 2015
	Last modified:	June 7, 2017
	This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - A0A0D9S2F1 (A0A0D9S2F1_CHLSB)

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Uncharacterized protein

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Caution

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A0D9S2F1 (A0A0D9S2F1_CHLSB)

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Uncharacterized protein

CASP3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ