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Protein

Tyrosine-protein kinase

Gene

SRC

Organism
Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:SRCImported
OrganismiChlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)Imported
Taxonomic identifieri60711 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeChlorocebus
Proteomesi
  • UP000029965 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 242SH3InterPro annotationAdd BLAST68
Domaini248 – 345SH2InterPro annotationAdd BLAST98
Domaini367 – 620Protein kinaseInterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118938.
OMAiCQCWRKD.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0D9RML6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDWRVDAI GISLSNDILK TVLRCLLYPC FADEDTEAQR GEVTCLGTHS
60 70 80 90 100
GERWRRASSS RPLTSHLVFV PRLQAASQVL WDSPCLLPAR TMGSNKSKPK
110 120 130 140 150
DASQRRRSLE PAENAHGAGG GAFPASQTPS KPASADGHRG PSAAFAPAAA
160 170 180 190 200
EPKLFGGFNS SDTVTSPQRA GPLAGGVTTF VALYDYESRT ETDLSFKKGE
210 220 230 240 250
RLQIVNNTRK VDVREGDWWL AHSLSTGQTG YIPSNYVAPS DSIQAEEWYF
260 270 280 290 300
GKITRRESER LLLNAENPRG TFLVRESETT KGAYCLSVSD FDNAKGLNVK
310 320 330 340 350
HYKIRKLDSG GFYITSRTQF NSLQQLVAYY SKHADGLCHR LTTVCPTSKP
360 370 380 390 400
QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT RVAIKTLKPG
410 420 430 440 450
TMSPEAFLQE AQVMKKLRHE KLVQLYAVVS EEPIYIVTEY MSKGSLLDFL
460 470 480 490 500
KGETGKYLRL PQLVDMAAQI ASGMAYVERM NYVHRDLRAA NILVGENLVC
510 520 530 540 550
KVADFGLARL IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI
560 570 580 590 600
LLTELTTKGR VPYPGMVNRE VLDQVERGYR MPCPPECPES LHDLMCQCWR
610 620 630
KEPEERPTFE YLQAFLEDYF TSTEPQYQPG ENL
Length:633
Mass (Da):70,730
Last modified:May 27, 2015 - v1
Checksum:i53A32DFEB008A499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIB01140704 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCSAT00000011792; ENSCSAP00000009855; ENSCSAG00000013699.

Similar proteinsi

Entry informationi

Entry nameiA0A0D9RML6_CHLSB
AccessioniPrimary (citable) accession number: A0A0D9RML6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: October 25, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported