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Protein
Submitted name:

Glucagon like peptide 1 receptor

Gene

GLP1R

Organism
Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Glucagon like peptide 1 receptorImported
Gene namesi
Name:GLP1RImported
OrganismiChlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)Imported
Taxonomic identifieri60711 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeChlorocebus
Proteomesi
  • UP000029965 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei145 – 167HelicalSequence analysisAdd BLAST23
Transmembranei179 – 196HelicalSequence analysisAdd BLAST18
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei268 – 287HelicalSequence analysisAdd BLAST20
Transmembranei307 – 332HelicalSequence analysisAdd BLAST26
Transmembranei353 – 370HelicalSequence analysisAdd BLAST18
Transmembranei382 – 405HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500234494024 – 464Sequence analysisAdd BLAST441

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 130G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST86
Domaini144 – 406G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST263

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118800.
OMAiRNSNMNY.

Family and domain databases

CDDicd15268. 7tmB1_GLP1R. 1 hit.
Gene3Di4.10.1240.10. 1 hit.
InterProiView protein in InterPro
IPR017981. GPCR_2-like.
IPR036445. GPCR_2_extracell_dom_sf.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
PANTHERiPTHR12011:SF245. PTHR12011:SF245. 1 hit.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiView protein in SMART
SM00008. HormR. 1 hit.
SUPFAMiSSF111418. SSF111418. 1 hit.
PROSITEiView protein in PROSITE
PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0D9REZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTPGPLRL ALLLLGVVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL
60 70 80 90 100
TEDPPPTTDL FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV
110 120 130 140 150
YRFCTAEGLW LQKDNSSLPW RDLSECEESK RGERSSPEEQ LLSLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILLGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLGCRVVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVF SEQRIFRLYV SVGWGVPLLF VVPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI
410 420 430 440 450
LYCFVNNEKV QLEFRKSWER WRLEHLHIQR DSSMKPLKCP TSSLSSGATA
460
GSSMYTATCQ ASCS
Length:464
Mass (Da):53,068
Last modified:May 27, 2015 - v1
Checksum:i503939E2394F59AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIB01159879 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCSAT00000009051; ENSCSAP00000007183; ENSCSAG00000010991.

Similar proteinsi

Entry informationi

Entry nameiA0A0D9REZ4_CHLSB
AccessioniPrimary (citable) accession number: A0A0D9REZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: November 22, 2017
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported