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Protein
Submitted name:

Leucine rich repeat kinase 2

Gene

LRRK2

Organism
Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Leucine rich repeat kinase 2Imported
Gene namesi
Name:LRRK2Imported
OrganismiChlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)Imported
Taxonomic identifieri60711 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeChlorocebus
Proteomesi
  • UP000029965 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1328 – 1511RocInterPro annotationAdd BLAST184
Domaini1879 – 2146Protein kinaseInterPro annotationAdd BLAST268

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili319 – 346Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063477.
KOiK08844.
OMAiFKIRDQP.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
1.25.40.20. 1 hit.
2.130.10.10. 1 hit.
3.80.10.10. 4 hits.
InterProiView protein in InterPro
IPR036770. Ankyrin_rpt-contain_sf.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032171. COR.
IPR011009. Kinase-like_dom_sf.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR005225. Small_GTP-bd_dom.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF16095. COR. 1 hit.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 1 hit.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 7 hits.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF50978. SSF50978. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 11 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0D9R4H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGSCQGCE EDEETLKKLI VRLNNVQEGK QIETLVQILE DLLVFTYSEH
60 70 80 90 100
ASKLFQGKNI HVPLLIVLDS YMRVASVQQV GWSLLCKLIE ICPGTMQSLM
110 120 130 140 150
GPQDVGNDWE VLGVHQLILK MLTVHNASVN LSMIGLKTLD LLLTSGKITL
160 170 180 190 200
LILDEESDIF MLIFDAMHSF PANDEIQKLG CKALHVLFER VSEEQLTEFV
210 220 230 240 250
ENKDYMILLS ALTNFKDEEE IVLHVLHCLH SLAIPCNNVE VLMSGNVRCY
260 270 280 290 300
NIVVEAMKAF PISEKIQEVS CCLLHRLTLG NFFNILVLNE VHEFVVKAVQ
310 320 330 340 350
RYPENAALQI SALSCLALLT ETIFLNQDLE EKNENQENDD EGEEVKLFWL
360 370 380 390 400
EACYKALTWH RKNKHVQEAA CWALNNLLMY QNSLHEKIGD EDGHFPAHRE
410 420 430 440 450
VMLSMLMHSS SKEVFQASAN ALSTLLEQNV NFRKILLSKG IYLNVLELMQ
460 470 480 490 500
KHIHSPEVAE SGCKMLNHLF EGSNTSLDTL AAVVPKIVTV MKSHETSLPV
510 520 530 540 550
QLEALRAILH FIAPGMPEES REDAESHRKL NMVKKQCFAN DIHKLVLAAL
560 570 580 590 600
NRFIGNPGIQ KCGLKVISSI AHFTNTLEVL SMEGAVDSVL HTLQMYPDDQ
610 620 630 640 650
EIQCLGLSLI GCLITKKNLC IGTGHLLAKI LASSLYRFKD VAEVQTEGFQ
660 670 680 690 700
TILAILKLSA SFSKLLVHHS FDLVIFHQMS SSIMEQKDQQ FLNLCCKCFA
710 720 730 740 750
KVAMDDDLKN VMLERACDQN NSIMAECLLL LGADANQAKE GTSLICQVCE
760 770 780 790 800
KESSPKLVEL LLNSGSREQD VRKALTISIG KGDSQIISLL LRRLALDMAN
810 820 830 840 850
NSICLGGFCI GKVEPSWLGP LFPDKTSNLR KQTNIASTLA RMVIRYQMKS
860 870 880 890 900
AVEEGAALGS DGNFSEDVLS KFDEWTFIPD SSMDSVFAQS DDLDSEGSEG
910 920 930 940 950
SFLVKKKSNS ISVGEFYRDA VLQRCSPNLQ RHSSSLGPIF DHEDLLRRKR
960 970 980 990 1000
KILSSDDSLR SSKLQSHVRH SDSISSLASE REYITSLDLS ANELRDIDAL
1010 1020 1030 1040 1050
SQKSCISGHL EHLEKLELHQ NALTSFPQQL CETLKSLTHL DLHSNKFTSF
1060 1070 1080 1090 1100
PSYLLKMSCV ANLDVSRNDI GPSVVLDPAV KCPTLKQFNL SYNQLSSVPE
1110 1120 1130 1140 1150
NLADVIEKLE QLILEGNKIS GICSPLRLKE LKILNLSKNH ISSLSENFLE
1160 1170 1180 1190 1200
ACPKVESFSA RMNFLAAMPF LPPSMTSLKL SQNKFTCIPE AILNLPHLRS
1210 1220 1230 1240 1250
LDMSSNDIQC LPGPAHWKSL NLRELLFSHN QISILDLSEK AYLWSRVEKL
1260 1270 1280 1290 1300
HLSHNKLKEI PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD
1310 1320 1330 1340 1350
ELRLNFDFKH IGCKAKDIIR FLQQRLKKAV PYNRMKLMVV GNTGSGKTTL
1360 1370 1380 1390 1400
LQQLMKTKKS DLGMQSATVG IDVKDWPIQI RGKRKRDLVL NVWDFAGREE
1410 1420 1430 1440 1450
FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA RASSSPVILV
1460 1470 1480 1490 1500
GTHLDVSDER QRKACISKIT KELLNKRGFP AIRDYHFVNA TEESDALAKL
1510 1520 1530 1540 1550
RKTIINESLN FKIRDQPVVG QLIPDCYVEL EKIILSERKN VPIEFPVIDQ
1560 1570 1580 1590 1600
KRLLQLVREN QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP
1610 1620 1630 1640 1650
KWLCKIMAQI LTVKVEGCPK HPKGIISRRD VEKFLSKKRR FPKNYMSQYF
1660 1670 1680 1690 1700
KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI ELPHCENSEI IIRLYEMPYF
1710 1720 1730 1740 1750
PMGFWSRLIN RLLEISPYML SGRERALRPN RMYWRQGIYL NWSPEAYCLV
1760 1770 1780 1790 1800
GSEVLDNHPE SFLKITVPSC RKGCILLGQV VDHIDSLMEE WFPGLLEIDI
1810 1820 1830 1840 1850
CGEGETLLKK WALYSFNDGE EHQKILLDDL MKKAEEGDLL VNPDQPRLTI
1860 1870 1880 1890 1900
PISQIAPDLI LADLPRNIML NNDELEFEQA PEFLLGDGSF GSVYRAAYEG
1910 1920 1930 1940 1950
EEVAVKIFNK HTSLRLLRQE LVVLCHLHHP SLISLLAAGI RPRMLVMELA
1960 1970 1980 1990 2000
SKGSLDRLLQ QDKASLTRTL QHRIALHVAD GLRYLHSAMI IYRDLKPHNV
2010 2020 2030 2040 2050
LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA PEVARGNVIY
2060 2070 2080 2090 2100
NQQADVYSFG LLLYDILTTG GRIVEGLKFP NEFDELAIQG KLPDPVKEYG
2110 2120 2130 2140 2150
CTPWPMVEKL ITKCLKENPQ ERPTSAQVFD ILNSAELVCL TRHILLPKNV
2160 2170 2180 2190 2200
IVDCMVATHH NSRNASIWLG CGHTDRGQLS FLDLNTEGYT SEEVADSRIL
2210 2220 2230 2240 2250
CLALVHLPVQ KESWIVSGTQ SGTLLVINTE DGKKRHTLEK MTDSITCLYC
2260 2270 2280 2290 2300
NSFSKQSKQK NFLLVGTADG NLAIFEDKTV KLEGAAPLKI LNIGNVSTPL
2310 2320 2330 2340 2350
MCLSESTNST ERNVMWGGCG TKIFSFSNDF TIQKLIETRT SQLFSYAAFS
2360 2370 2380 2390 2400
DSNIVTVVVD TALYIAKKNS PVVEVWDKKT EKLCELIDCV HFLREVMVKV
2410 2420 2430 2440 2450
NKESKHKMSY SGRVKALCLQ KNTALWIGTG GGHILLLDLS TRRVIRIIYN
2460 2470 2480 2490 2500
FCDSVRVMMT AQLGSLKNVM LVLGYNRKST EGTQQQKEIQ SCLTVWDINL
2510 2520
PHEVQNLEKH IEVRKELAEK MRGTSIE
Length:2,527
Mass (Da):285,091
Last modified:May 27, 2015 - v1
Checksum:i35E77A40A179C95E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIB01022566 Genomic DNA. No translation available.
AQIB01022567 Genomic DNA. No translation available.
RefSeqiXP_008001071.1. XM_008002880.1.

Genome annotation databases

EnsembliENSCSAT00000005293; ENSCSAP00000003518; ENSCSAG00000007254.
GeneIDi103238159.
KEGGicsab:103238159.

Similar proteinsi

Entry informationi

Entry nameiA0A0D9R4H9_CHLSB
AccessioniPrimary (citable) accession number: A0A0D9R4H9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: November 22, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported