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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptomyces griseus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei740ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:BF14_6546Imported
OrganismiStreptomyces griseusImported
Taxonomic identifieri1911 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000032367 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 177tRNA-synt_1gInterPro annotationAdd BLAST104
Domaini302 – 507tRNA-synt_1_2InterPro annotationAdd BLAST206
Domaini815 – 927Anticodon_1InterPro annotationAdd BLAST113

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi737 – 741"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0D6UKR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDGALRIM SETNSAAETA APHRYTAAMA ADIEARWQDF WDAEGTYEAP
60 70 80 90 100
NPTGDLAGDP ELAAKPKKFI MDMFPYPSGA GLHVGHPLGY IATDVYARHQ
110 120 130 140 150
RMTGHNVLHT LGFDAFGLPA EQYAVQTGTH PRVSTEANME NMKVQLRRLG
160 170 180 190 200
LGHDNRRSFA TIEAEYYKWT QWIFLQIFNS WYDAEADKAR PIAELVEQFE
210 220 230 240 250
SGTRATPDGR EWSALSATER ADLLSQYRLA YASDAPVNWS PGLGTVLANE
260 270 280 290 300
EVTADGRSER GNFPVFKAKL RQWNMRITAY ADRLLNDLDG LDWPEAIKLQ
310 320 330 340 350
QRNWIGRSEG ARVEFPVDTA GGITVFTTRQ DTLFGATYMV LAPEHDMVER
360 370 380 390 400
IIPAAWPEGT HPVWTGGHAS PAEAVTAYRK QAAAKSDVER QAEAKDKTGV
410 420 430 440 450
FTGAYATNPV SGEKVPVFIA DYVLMGYGTG AIMAVPAHDA RDFAFARAFE
460 470 480 490 500
LPMRCVVQPS DDRGTDPATW DDAFSSYDAK LVNSANDEIS LDGLGVVEAK
510 520 530 540 550
AKITDWLREH GVGEGTVNFR LRDWLFSRQR YWGEPFPIVY DEEGIAHALP
560 570 580 590 600
ESMLPLELPE VEDYSPRTFD PEDASAQPET PLSRNADWVN VTLDLGDGAG
610 620 630 640 650
PRKYRRETNT MPNWAGSCWY ELRYLDPNND RQLVDPSIEQ YWMGPREGQP
660 670 680 690 700
TGGVDLYVGG AEHAVLHLLY ARFWSKVLHD LGHISSAEPF HKLYNQGMIQ
710 720 730 740 750
AFVYRDSRGI AVPAAEVEER DGAFYYEGEK VSRVLGKMGK SLKNAVTPDE
760 770 780 790 800
ICAEYGADTL RLYEMAMGPL DVSRPWDTRA VVGQYRLLQR LWRNVVDEET
810 820 830 840 850
GEVTVVDTEP GEDTLRALHK AIDGVGQDMA GMRFNTAIAK VTELNNHLTK
860 870 880 890 900
AGGPLARSVA ERLVLLIAPL APHIAEELWR RLGHTDSVVH QDFPVADPAY
910 920 930 940 950
VVDETVTCVV QIKGKVRARL EISPSITDEE LEALALADDA VVAALGGAGI
960
RKVIVRAPKL VNIVPA
Length:966
Mass (Da):107,022
Last modified:May 27, 2015 - v1
Checksum:i3AC6104A7DFD284C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JYBE01000122 Genomic DNA. Translation: KIX32527.1.

Genome annotation databases

EnsemblBacteriaiKIX32527; KIX32527; BF14_6546.
PATRICifig|1911.7.peg.1328.

Similar proteinsi

Entry informationi

Entry nameiA0A0D6UKR7_STRGR
AccessioniPrimary (citable) accession number: A0A0D6UKR7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: March 28, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported